ArticleEukaryotic cell2006
The phosducin-like protein PhnA is required for Gbetagamma-mediated signaling for vegetative growth, developmental control, and toxin biosynthesis in Aspergillus nidulans.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Regulators of the Asexual Life Cycle ofCells · 2023Review
- Phosducin-like proteinFrontiers in microbiology · 2023Article
- Review
- Construction of a Codon-Adapted Nourseotricin-Resistance Marker Gene for Efficient Targeted Gene Deletion in the Mycophenolic Acid ProducerJournal of fungi (Basel, Switzerland) · 2019Article
- GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production.PLoS genetics · 2019Article
- Effects of Different G-Protein α-Subunits on Growth, Development and Secondary Metabolism ofFrontiers in microbiology · 2019Article
- Cloning and functional analysis of the Gβ gene Mgb1 and the Gγ gene Mgg1 in Monascus ruber.Journal of microbiology (Seoul, Korea) · 2014Article
- Expression and Activity of Catalases Is Differentially Affected by GpaA (Ga) and FlbA (Regulator of G Protein Signaling) in Aspergillus fumigatus.Mycobiology · 2013Article
- Development in Aspergillus.Studies in mycology · 2013Article
- The late endosomal HOPS complex anchors active G-protein signaling essential for pathogenesis in magnaporthe oryzae.PLoS pathogens · 2013Article
- Gβ-like CpcB plays a crucial role for growth and development of Aspergillus nidulans and Aspergillus fumigatus.PloS one · 2013Article
- Isolation and analysis of differentially expressed genes during asexual sporulation in liquid static culture of Ganoderma lucidum by suppression subtractive hybridization.Molecular biology reports · 2012Article
- The phosducin-like protein PhLP1 impacts regulation of glycoside hydrolases and light response in Trichoderma reesei.BMC genomics · 2011Article
- Regulators of G-protein signalling in Fusarium verticillioides mediate differential host-pathogen responses on nonviable versus viable maize kernels.Molecular plant pathology · 2011Article
- Phosphorylation of phosducin-like protein BDM-1 by protein kinase 2 (CK2) is required for virulence and G beta subunit stability in the fungal plant pathogen Cryphonectria parasitica.Molecular microbiology · 2010Article
- How a mycoparasite employs g-protein signaling: using the example of trichoderma.Journal of signal transduction · 2010Article
- Gbetagamma-mediated growth and developmental control in Aspergillus fumigatus.Current genetics · 2009Article
- Differential roles of the ChiB chitinase in autolysis and cell death of Aspergillus nidulans.Eukaryotic cell · 2009Article
- The information highways of a biotechnological workhorse--signal transduction in Hypocrea jecorina.BMC genomics · 2008Article
- Growth and developmental control in the model and pathogenic aspergilli.Eukaryotic cell · 2006Review
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosducin or phosducin-like protein (PhLP) is a positive regulator of Gbetagamma activity. The Gbeta (SfaD) and Ggamma (GpgA) subunits function in vegetative growth and developmental control in the model filamentous fungus Aspergillus nidulans. To better understand the nature of Gbetagamma-mediated signaling, phnA, encoding an A. nidulans PhLP, has been studied. Deletion of phnA resulted in phenotypes almost identical to those caused by deletion of sfaD, i.e., reduced biomass, asexual sporulation in liquid submerged culture, and defective fruiting body formation, suggesting that PhnA is necessary for Gbeta function. The requirement for the RGS protein FlbA in asexual sporulation could be bypassed by the DeltaphnA mutation, indicating that PhnA functions in FlbA-controlled vegetative growth signaling, primarily mediated by the heterotrimeric G protein composed of FadA (Galpha), SfaD, and GpgA. However, whereas deletion of fadA restored both asexual sporulation and the production of sterigmatocystin (ST), deletion of sfaD, gpgA, or phnA failed to restore ST production in the DeltaflbA mutant. Further studies revealed that SfaD, GpgA, and PhnA are necessary for the expression of aflR, encoding the transcriptional activator for the ST biosynthetic genes, and subsequent ST biosynthesis. Overexpression of aflR bypassed the need for SfaD in ST production, indicating that the results of SfaD-mediated signaling may include transcriptional activation of aflR. Potential differential roles of FadA, Gbetagamma, and FlbA in controlling ST biosynthesis are further discussed.
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