ArticleEukaryotic cell2006
Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Aloin remodels the cell wall of Candida albicans to reduce its hyphal virulence against oral candidiasis.Applied microbiology and biotechnology · 2025Article
- The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans.Nature communications · 2024Article
- Protein markers forJournal of extracellular vesicles · 2020Article
- Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic YeastAntibiotics (Basel, Switzerland) · 2019Article
- Multifunction of the ER P-Type Calcium Pump Spf1 During Hyphal Development in Candida albicans.Mycopathologia · 2019Article
- Multi-omics Analyses Reveal Synergistic Carbohydrate Metabolism in Streptococcus mutans-Candida albicans Mixed-Species Biofilms.Infection and immunity · 2019Article
- Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.The Biochemical journal · 2016Article
- Budding off: bringing functional genomics to Candida albicans.Briefings in functional genomics · 2016Review
- The Candida albicans Exocyst Subunit Sec6 Contributes to Cell Wall Integrity and Is a Determinant of Hyphal Branching.Eukaryotic cell · 2015Article
- β-catenin in plants and animals: common players but different pathways.Frontiers in plant science · 2014Article
- PsVPS1, a dynamin-related protein, is involved in cyst germination and soybean infection of Phytophthora sojae.PloS one · 2013Article
- Infection-associated nuclear degeneration in the rice blast fungus Magnaporthe oryzae requires non-selective macro-autophagy.PloS one · 2012Article
- Candida albicans SH3-domain proteins involved in hyphal growth, cytokinesis, and vacuolar morphology.Current genetics · 2010Article
- Role for endosomal and vacuolar GTPases in Candida albicans pathogenesis.Infection and immunity · 2009Article
- Vacuole inheritance regulates cell size and branching frequency of Candida albicans hyphae.Molecular microbiology · 2009Article
- Morphogenesis and cell cycle progression in Candida albicans.Current opinion in microbiology · 2006Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Hyphal growth is prevalent during most Candida albicans infections. Current cell division models, which are based on cytological analyses of C. albicans, predict that hyphal branching is intimately linked with vacuolar inheritance in this fungus. Here we report the molecular validation of this model, showing that a specific mutation that disrupts vacuolar inheritance also affects hyphal division. The armadillo repeat-containing protein Vac8p plays an important role in vacuolar inheritance in Saccharomyces cerevisiae. The VAC8 gene was identified in the C. albicans genome sequence and was resequenced. Homozygous C. albicans vac8Delta deletion mutants were generated, and their phenotypes were examined. Mutant vac8Delta cells contained fragmented vacuoles, and minimal vacuolar material was inherited by daughter cells in hyphal or budding forms. Normal rates of growth and hyphal extension were observed for the mutant hyphae on solid serum-containing medium. However, branching frequencies were significantly increased in the mutant hyphae. These observations are consistent with a causal relationship between vacuolar inheritance and the cell division cycle in the subapical compartments of C. albicans hyphae. The data support the hypothesis that cytoplasmic volume, rather than cell size, is critical for progression through G1.
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