ArticleEukaryotic cell2006
Rac1 and Cdc42 have different roles in Candida albicans development.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 80 citations in OpenAlex.
- Functionally redundant Rho GTPases Cdc42 and RacA regulate aflatoxin synthesis and pathogenicity inMycology · 2026Article
- Trans-cellular tunnels induced by the fungal pathogen Candida albicans facilitate invasion through successive epithelial cells without host damage.Nature communications · 2022Article
- Article
- From Jekyll to Hyde: The Yeast-Hyphal Transition ofPathogens (Basel, Switzerland) · 2021Review
- The ESCRT System Plays an Important Role in the Germination in Candida albicans by Regulating the Expression of Hyphal-Specific Genes and the Localization of Polarity-Related Proteins.Mycopathologia · 2020Article
- Transcriptional control of hyphal morphogenesis in Candida albicans.FEMS yeast research · 2020Review
- Protein markers forJournal of extracellular vesicles · 2020Article
- Lrg1 Regulates β (1,3)-Glucan Masking in Candida albicans through the Cek1 MAP Kinase Pathway.mBio · 2019Article
- Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway.PLoS genetics · 2019Article
- Genome-Wide Screen for Haploinsufficient Cell Size Genes in the Opportunistic YeastG3 (Bethesda, Md.) · 2017Article
- RacA-Mediated ROS Signaling Is Required for Polarized Cell Differentiation in Conidiogenesis of Aspergillus fumigatus.PloS one · 2016Article
- Fungal morphogenesis.Cold Spring Harbor perspectives in medicine · 2014Review
- Small-GTPase-associated signaling by the guanine nucleotide exchange factors CpDock180 and CpCdc24, the GTPase effector CpSte20, and the scaffold protein CpBem1 in Claviceps purpurea.Eukaryotic cell · 2014Article
- Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformans.Fungal genetics and biology : FG & B · 2013Article
- Ras1 acts through duplicated Cdc42 and Rac proteins to regulate morphogenesis and pathogenesis in the human fungal pathogen Cryptococcus neoformans.PLoS genetics · 2013Article
- Article
- A steep phosphoinositide bis-phosphate gradient forms during fungal filamentous growth.The Journal of cell biology · 2012Article
- Review
- Hypoxia and fungal pathogenesis: to air or not to air?Eukaryotic cell · 2012Review
- Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans.Eukaryotic cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the role of the highly conserved G protein Rac1 in the opportunistic pathogen Candida albicans. We identified and disrupted RAC1 and show here that, in contrast to CDC42, it is not necessary for viability or serum-induced hyphal growth but is essential for filamentous growth when cells are embedded in a matrix. Rac1 is localized to the plasma membrane, yet its distribution is more homogenous than that of Cdc42, with no enrichment at the tips of either buds or hyphae. In addition, fluorescence recovery after photobleaching results indicate that Rac1 and Cdc42 have different dynamics at the membrane. Furthermore, overexpression of Rac1 does not complement Cdc42 function, and conversely, overexpression of Cdc42 does not complement Rac1 function. Thus, Rac1 and Cdc42, although highly similar to one another, have different roles in C. albicans development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.