ArticleEukaryotic cell2006
Differential expression of Aspergillus nidulans ammonium permease genes is regulated by GATA transcription factor AreA.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- B-GATA factors are required for nitrogen-responsive growth in Physcomitrium patens and Arabidopsis thaliana.The New phytologist · 2026Article
- Hyphae of the fungus Aspergillus nidulans demonstrate chemotropism to nutrients and pH.PLoS biology · 2024Article
- Characterization and engineering of the xylose-inducibleMetabolic engineering communications · 2022Article
- The Exploring Functional Role of Ammonium Transporters ofInternational journal of molecular sciences · 2022Article
- Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions inJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.Genome biology · 2017Article
- The AreA transcription factor mediates the regulation of deoxynivalenol (DON) synthesis by ammonium and cyclic adenosine monophosphate (cAMP) signalling in Fusarium graminearum.Molecular plant pathology · 2015Article
- Spatial differentiation of gene expression in Aspergillus niger colony grown for sugar beet pulp utilization.Scientific reports · 2015Article
- Characterization of three ammonium transporters of the glomeromycotan fungus Geosiphon pyriformis.Eukaryotic cell · 2013Article
- High-throughput genome sequencing of lichenizing fungi to assess gene loss in the ammonium transporter/ammonia permease gene family.BMC genomics · 2013Article
- Kinetics of NH (4) (+) uptake by the arbuscular mycorrhizal fungus Rhizophagus irregularis.Mycorrhiza · 2012Article
- Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.Genetics · 2011Article
- The bZIP transcription factor MeaB mediates nitrogen metabolite repression at specific loci.Eukaryotic cell · 2010Article
- Sumoylation in Aspergillus nidulans: sumO inactivation, overexpression and live-cell imaging.Fungal genetics and biology : FG & B · 2008Article
- Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi.Eukaryotic cell · 2008Article
- Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans.Eukaryotic cell · 2008Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The movement of ammonium across biological membranes is mediated in both prokaryotes and eukaryotes by ammonium transport proteins (AMT/MEP) that constitute a family of related sequences. We have previously identified two ammonium permeases in Aspergillus nidulans, encoded by the meaA and mepA genes. Here we show that meaA is expressed in the presence of ammonium, consistent with the function of MeaA as the main ammonium transporter required for optimal growth on ammonium as a nitrogen source. In contrast, mepA, which encodes a high-affinity ammonium permease, is expressed only under nitrogen-limiting or starvation conditions. We have identified two additional AMT/MEP-like genes in A. nidulans, namely, mepB, which encodes a second high-affinity ammonium transporter expressed only in response to complete nitrogen starvation, and mepC, which is expressed at low levels under all nitrogen conditions. The MepC gene product is more divergent than the other A. nidulans AMT/MEP proteins and is not thought to significantly contribute to ammonium uptake under normal conditions. Remarkably, the expression of each AMT/MEP gene under all nitrogen conditions is regulated by the global nitrogen regulatory GATA factor AreA. Therefore, AreA is also active under nitrogen-sufficient conditions, along with its established role as a transcriptional activator in response to nitrogen limitation.
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