ArticleJournal of the American Society of Nephrology : JASN2006
Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis.
Article in Journal of the American Society of Nephrology : JASN, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 93 citations in OpenAlex.
- Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis.Physiological reviews · 2023Review
- A Systematic Review of the Evidence of Hematopoietic Stem Cell Differentiation to Fibroblasts.Biomedicines · 2022Review
- Cellular Origin and Functional Relevance of Collagen I Production in the Kidney.Journal of the American Society of Nephrology : JASN · 2018Article
- Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis.JCI insight · 2018Article
- Tumor-associated fibroblasts predominantly come from local and not circulating precursors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Role of Bone Marrow-Derived Fibroblasts in Renal Fibrosis.Frontiers in physiology · 2016Review
- Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells.Kidney international · 2015Article
- Diverse origins of the myofibroblast—implications for kidney fibrosis.Nature reviews. Nephrology · 2015Review
- Renal erythropoietin-producing cells in health and disease.Frontiers in physiology · 2015Review
- Macrophages promote renal fibrosis through direct and indirect mechanisms.Kidney international supplements · 2014Review
- The chemokine receptor CXCR6 contributes to recruitment of bone marrow-derived fibroblast precursors in renal fibrosis.Kidney international · 2014Article
- Matrix Producing Cells in Chronic Kidney Disease: Origin, Regulation, and Activation.Current pathobiology reports · 2013Article
- Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis.Frontiers in endocrinology · 2013Article
- The origin of interstitial myofibroblasts in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2012Review
- TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis.Cell and tissue research · 2012Review
- Cellular and molecular mechanisms of renal fibrosis.Nature reviews. Nephrology · 2011Review
- CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis.Journal of the American Society of Nephrology : JASN · 2011Article
- Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.The Journal of clinical investigation · 2011Article
- Mesenchymal stem cells: from experiment to clinic.Fibrogenesis & tissue repair · 2011Article
- Fibroblasts and myofibroblasts in renal fibrosis.International journal of experimental pathology · 2011Review
Corrections and comments
- Commented on by
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Interstitial fibroblasts play a central role in kidney fibrosis. Their origin is debated, with recent data indicating a contribution of bone marrow (BM)-derived cells to the expanded population of interstitial cells after kidney damage in animals and humans. This study investigated whether these BM-derived cells would respond appropriately to a fibrotic drive by producing collagen. A transgenic mouse that expresses both luciferase and beta-galactosidase reporter molecules under the control of a 17-kb promoter and enhancer element of the gene encoding the alpha2 chain of the collagen I was used. Male transgenic BM was transplanted into female wild-type C57BL/6 mice (n=14), and unilateral ureteric obstruction was performed later to induce renal fibrosis. In the obstructed kidney of the BM-chimeric female mice, a mean of 8.6% of smooth muscle actin-positive interstitial cells were Y chromosome positive. Increased collagen I mRNA in the obstructed kidney was detected by in situ hybridization. No luciferase activity was detected by enzyme assays in tissue homogenates of BM recipients, and very few luciferase mRNA transcripts were seen, mainly in tubular cells. beta-Galactosidase activity was not a useful reporter molecule because it could not be distinguished from enhanced endogenous beta-galactosidase activity in the obstructed kidney. These results indicate that BM-derived interstitial cells do not make a significant contribution to collagen I synthesis in the context of renal injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.