ArticleMolecular biology of the cell2006
H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors.Molecular oncology · 2017Article
- Different effects of prolonged β-adrenergic stimulation on heart and cerebral artery.Integrative medicine research · 2014Review
- R-Ras contributes to LTP and contextual discrimination.Neuroscience · 2014Article
- β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.Molecular and cellular biology · 2012Article
- siRNA-mediated downregulation of TC21 sensitizes esophageal cancer cells to cisplatin.World journal of gastroenterology · 2012Article
- Beta adrenergic overstimulation impaired vascular contractility via actin-cytoskeleton disorganization in rabbit cerebral artery.PloS one · 2012Article
- Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.Development (Cambridge, England) · 2010Article
- TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis.Journal of the American Society of Nephrology : JASN · 2010Article
- ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events.Molecular cell · 2010Article
- Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors.Molecular biology of the cell · 2009Article
- Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells.Experimental cell research · 2008Article
- ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis.Molecular biology of the cell · 2007Article
- Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
The collecting system of the kidney, derived from the ureteric bud (UB), undergoes repetitive bifid branching events during early development followed by a phase of tubular growth and elongation. Although members of the Ras GTPase family control cell growth, differentiation, proliferation, and migration, their role in development of the collecting system of the kidney is unexplored. In this study, we demonstrate that members of the R-Ras family of proteins, R-Ras and TC21, are expressed in the murine collecting system at E13.5, whereas H-Ras is only detected at day E17.5. Using murine UB cells expressing activated H-Ras, R-Ras, and TC21, we demonstrate that R-Ras-expressing cells show increased branching morphogenesis and cell growth, TC21-expressing cells branch excessively but lose their ability to migrate, whereas H-Ras-expressing cells migrated the most and formed long unbranched tubules. These differences in branching morphogenesis are mediated by differential regulation/activation of the Rho family of GTPases and mitogen-activated protein kinases. Because most branching of the UB occurs early in development, it is conceivable that R-Ras and TC-21 play a role in facilitating branching and growth in early UB development, whereas H-Ras might favor cell migration and elongation of tubules, events that occur later in development.
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