ArticleMolecular biology of the cell2006
Role of LIM kinases in normal and psoriatic human epidermis.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- LIM kinases in cardiovascular health and disease.Frontiers in physiology · 2024Review
- The role of actin cytoskeleton CFL1 and ADF/cofilin superfamily in inflammatory response.Frontiers in molecular biosciences · 2024Review
- Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer.Cancers · 2021Article
- New susceptibility loci for cutaneous melanoma risk and progression revealed using a porcine model.Oncotarget · 2018Article
- Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation.Gut microbes · 2017Article
- Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema.The Journal of allergy and clinical immunology · 2017Article
- Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.Journal of medicinal chemistry · 2015Article
- BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions.Stem cell reports · 2014Article
- EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers.International journal of molecular sciences · 2013Review
- The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.The Journal of cell biology · 2013Article
- Article
- MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.Molecular and cellular biology · 2012Article
- Angiogenic sprouting requires the fine tuning of endothelial cell cohesion by the Raf-1/Rok-α complex.Developmental cell · 2012Article
- Ras and Raf pathways in epidermis development and carcinogenesis.British journal of cancer · 2011Review
- Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions.Nature cell biology · 2010Article
- Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor.The Journal of clinical investigation · 2010Article
- Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation.EMBO molecular medicine · 2010Article
- Manipulating actin dynamics affects human in vitro decidualization.Biology of reproduction · 2009Article
- Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice.The Journal of clinical investigation · 2009Article
- An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth.The Journal of cell biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present evidence that LIM kinases can control cell adhesion and compaction in human epidermis. LIMK2 is expressed in the epidermal basal layer and signals downstream of the GTPase Rac1 to promote extracellular matrix adhesion and inhibit terminal differentiation. Conversely, LIMK1 is expressed in the upper granular layers and phosphorylates and inhibits cofilin. Expression of LIMK1 is lost in psoriatic lesions and other skin disorders characterized by lack of cell compaction in the differentiating cell layers. In psoriatic lesions down-regulation of LIMK1 correlates with up-regulation of Myc. Expression of constitutively active cofilin or Myc in reconstituted human epidermis blocks cell compaction. Overexpression of LIMK1 leads to down-regulation of Myc, whereas inhibition of Rho kinase, an upstream activator of LIMK1, stimulates Myc expression. Inhibition of Myc by LIMK1 is via inhibition of Stat3 phosphorylation, because constitutively active cofilin or inhibition of Rho kinase results in Stat3 phosphorylation and increased Myc levels, whereas dominant negative Stat3 abolishes the effect. In conclusion, we have uncovered a novel antagonistic relationship between the LIMK1/phosphocofilin and Myc/Stat3 pathways in the differentiating layers of human epidermis and propose that down-regulation of LIMK1 contributes to one of the pathological features of psoriatic epidermal lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.