Trial reportBMJ (Clinical research ed.)2006
Oral protein energy supplements for children with cystic fibrosis: CALICO multicentre randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Protein supplementation in pediatric oncology: a systematic review revealing a lack of evidence and insights from other chronically and critically ill children.Frontiers in pediatrics · 2025Pooled it
- Appetite stimulants for people with cystic fibrosis.The Cochrane database of systematic reviews · 2022Pooled it
- Oral calorie supplements for cystic fibrosis.The Cochrane database of systematic reviews · 2017Pooled it
- Oral protein calorie supplementation for children with chronic disease.The Cochrane database of systematic reviews · 2015Pooled it
- Impact of high energy oral nutritional supplements consumed in the late afternoon on appetite, energy intake and cardio-metabolic risk factors in females with lower BMI.European journal of clinical nutrition · 2022Trial
- Dietary essential amino acids are highly anabolic in pediatric patients with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2013Trial
- Brazilian Guidelines for Nutrition in Cystic Fibrosis.Einstein (Sao Paulo, Brazil) · 2022Article
- Oral Nutritional Supplements in Adults with Cystic Fibrosis: Effects on Intake, Levels of Fat-Soluble Vitamins, and Bone Remodeling Biomarkers.Nutrients · 2021Article
- What Can Meal Observations Tell Us about Eating Behavior in Malnourished Children?International journal of environmental research and public health · 2019Article
- Ready-to-Use Supplemental Food for Nutritional Supplementation in Cystic Fibrosis.Current developments in nutrition · 2019Article
- Macronutrient intake in preschoolers with cystic fibrosis and the relationship between macronutrients and growth.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2017Article
- Pathophysiology of cystic fibrosis and drugs used in associated digestive tract diseases.World journal of gastroenterology · 2013Review
- Comparison of treatment effect sizes associated with surrogate and final patient relevant outcomes in randomised controlled trials: meta-epidemiological study.BMJ (Clinical research ed.) · 2013Review
- Nutritional outcomes following gastrostomy in children with cystic fibrosis.Pediatric pulmonology · 2012Article
- Article
- Exacerbations in cystic fibrosis: 2 . prevention.Thorax · 2007Review
- Nutritional supplements in cystic fibrosis.BMJ (Clinical research ed.) · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether oral protein energy supplements, used long term in children with cystic fibrosis who are moderately malnourished, improve nutritional and other outcomes.
designMulticentre randomised controlled trial.
settingSeven specialist paediatric cystic fibrosis centres and their associated shared care clinics and seven smaller paediatric cystic fibrosis clinics.
participants102 children with cystic fibrosis, aged between 2 and 15 years, who were moderately malnourished.
interventionsOral protein energy supplements in addition to usual dietary advice compared with dietary advice alone, for 12 months.
main outcome measureChange in body mass index centile over one year.
resultsUse of supplements was not associated with a change in body mass index centile (mean difference 2.99 centile points, 95% confidence interval -2.70 to 8.68) or other nutritional and spirometric outcomes in this group of children.
conclusionsLong term use of oral protein energy supplements did not result in an improvement in nutritional status or other clinical outcomes in children with cystic fibrosis who were moderately malnourished. Oral protein energy supplements should not be regarded as an essential part of the management of this group of children.
trial registrationISRCTN: 95744468.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.