ArticleProceedings of the National Academy of Sciences of the United States of America2006
Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 93 citations in OpenAlex.
- Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Urotensin II system in chronic kidney disease.Current research in physiology · 2024Review
- Article
- The network map of urotensin-II mediated signaling pathway in physiological and pathological conditions.Journal of cell communication and signaling · 2022Article
- Reconstructing the Origins of the Somatostatin and Allatostatin-C Signaling Systems Using the Accelerated Evolution of Biodiverse Cone Snail Toxins.Molecular biology and evolution · 2022Article
- Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod.Open biology · 2021Article
- Development of NovelBiomolecules · 2020Article
- Nitric Oxide and the Neuroendocrine Control of the Osmotic Stress Response in Teleosts.International journal of molecular sciences · 2019Review
- The G Protein-Coupled Receptor UT of the Neuropeptide Urotensin II Displays Structural and Functional Chemokine Features.Frontiers in endocrinology · 2017Review
- Identification of prohormones and pituitary neuropeptides in the African cichlid, Astatotilapia burtoni.BMC genomics · 2016Article
- Article
- Dynamic expression pattern of corticotropin-releasing hormone, urotensin I and II genes under acute salinity and temperature challenge during early development of zebrafish.Fish physiology and biochemistry · 2014Article
- RGS2 regulates urotensin II-induced intracellular Ca2+ elevation and contraction in glomerular mesangial cells.Journal of cellular physiology · 2014Article
- Article
- Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems.Journal of molecular neuroscience : MN · 2012Article
- Article
- Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.Endocrinology · 2011Article
- Urotensin I-CRF-Urocortins: a mermaid's tail.General and comparative endocrinology · 2009Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although urotensin II (UII) and somatostatin 1 (SS1) exhibit some structural similarities, their precursors do not show any appreciable sequence identity and, thus, it is widely accepted that the UII and SS1 genes do not derive from a common ancestral gene. The recent characterization of novel isoforms of these two peptides, namely urotensin II-related peptide (URP) and somatostatin 2 (SS2)/cortistatin (CST), provides new opportunity to revisit the phylogenetic relationships of UII and SS1 using a comparative genomics approach. In the present study, by radiation hybrid mapping and in silico sequence analysis, we have determined the chromosomal localization of the genes encoding UII- and somatostatin-related peptides in several vertebrate species, including human, chicken, and zebrafish. In most of the species investigated, the UII and URP genes are closely linked to the SS2/CST and SS1 genes, respectively. We also found that the UII-SS2/CST locus and the URP/SS1 locus are paralogous. Taken together, these data indicate that the UII and URP genes, on the one hand, and the SS1 and SS2/CST genes, on the other hand, arose through a segmental duplication of two ancestral genes that were already physically linked to each other. Our results also suggest that these two genes arose themselves through a tandem duplication of a single ancestral gene. It thus appears that the genes encoding UII- and somatostatin-related peptides belong to the same superfamily.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.