ArticleProceedings of the National Academy of Sciences of the United States of America2006
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders.The Journal of clinical investigation · 2025Article
- Aging and Protein Kinases.Advances in experimental medicine and biology · 2021Article
- Article
- Review
- Evaluating biomarkers to model cancer risk post cosmic ray exposure.Life sciences in space research · 2016Review
- ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells.Cell reports · 2015Article
- Article
- Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance.BioMed research international · 2014Review
- DNA repair at telomeres: keeping the ends intact.Cold Spring Harbor perspectives in biology · 2013Review
- Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening.Frontiers in oncology · 2013Article
- Multiple roles of ATM in monitoring and maintaining DNA integrity.FEBS letters · 2010Review
- ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.The Journal of cell biology · 2010Article
- A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.PLoS genetics · 2010Article
- Short telomeres initiate telomere recombination in primary and tumor cells.PLoS genetics · 2009Article
- ATM-like kinases and regulation of telomerase: lessons from yeast and mammals.Trends in cell biology · 2008Review
- Short telomeres limit tumor progression in vivo by inducing senescence.Cancer cell · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Telomerase-mediated telomere addition counteracts telomere shortening due to incomplete DNA replication. Short telomeres are the preferred substrate for telomere addition by telomerase; however, the mechanism by which telomerase recognizes short telomeres is unclear. In yeast, the Ataxia telangiectasia mutated (Atm) homolog, Tel1, is necessary for normal telomere length regulation likely by altering telomere structure, allowing telomerase recruitment to short telomeres. To examine the role of Atm in establishing preference for elongation of short telomeres in mice, we examined telomerase-mediated elongation of short dysfunctional telomeres in the presence or absence of Atm. Here we show that Atm is dispensable for elongation of short telomeres by telomerase, suggesting that telomerase recruitment in mammalian cells and in yeast may be regulated differently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.