ArticleThorax2006
Longitudinal pulmonary function of childhood bronchiectasis and comparison with cystic fibrosis.
Article in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02564731 (Prognosis of Bronchiectasis in Children--A Multicenter Prospective Cohort Study), which is not on this map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognosis of Bronchiectasis in Children--A Multicenter Prospective Cohort Study
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Inhaled corticosteroids for bronchiectasis.The Cochrane database of systematic reviews · 2018Pooled it
- Combination inhaled corticosteroids and long-acting beta2-agonists for children and adults with bronchiectasis.The Cochrane database of systematic reviews · 2014Pooled it
- Pneumococcal vaccines for children and adults with bronchiectasis.The Cochrane database of systematic reviews · 2009Pooled it
- Oral non steroid anti-inflammatories for children and adults with bronchiectasis.The Cochrane database of systematic reviews · 2007Pooled it
- Influenza vaccine for children and adults with bronchiectasis.The Cochrane database of systematic reviews · 2007Pooled it
- Greater disease severity in adults with paediatric-onsetThe European respiratory journal · 2026Article
- Article
- Lung function trajectories in children with early diagnosis of non-cystic fibrosis bronchiectasis: a retrospective observational study.Italian journal of pediatrics · 2024Observational
- Monitoring disease progression in childhood bronchiectasis.Frontiers in pediatrics · 2022Review
- Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management.Immunology and allergy clinics of North America · 2020Review
- The Role of the Immune Response in the Pathogenesis of Bronchiectasis.BioMed research international · 2018Review
- Chronic Suppurative Lung Disease in Children: Definition and Spectrum of Disease.Frontiers in pediatrics · 2017Review
- Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis.Paediatric respiratory reviews · 2011Article
- Association between mucoid Pseudomonas infection and bronchiectasis in children with cystic fibrosis.Radiology · 2009Article
- The pathophysiology of bronchiectasis.International journal of chronic obstructive pulmonary disease · 2009Review
- Lung Disease in Primary Antibody Deficiencies.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle has been published on the progression of non-cystic fibrosis bronchiectasis (BX), especially in childhood. Data are needed for prognosis and evaluation of the effectiveness of treatments. A study was undertaken to evaluate the change in lung function over time in children with BX, and to consider covariates and compare them with the local cystic fibrosis (CF) population.
methodsChildren with BX or CF and > or =3 calendar years of lung function data were identified from hospital clinics. Diagnosis was made by high resolution CT scans, sweat tests, and genetic studies. Lung function performed on a single plethysmograph between 6 and 15 years of age and > or =6 weeks after diagnosis was analysed longitudinally (linear mixed model). The impact of reference equation and "best annual" versus "all data" approaches were evaluated.
resultsThere were 44 children in each of the BX and CF groups with an overall mean 5.7 calendar years follow up data. The estimated forced expiratory volume in 1 second (FEV(1)) in the BX group had an intercept of 68% predicted (Polgar) at 10 years of age which fell at a rate of 1.9% per annum using "best annual" data compared with 63% and 0.9% using "all data". Those with post-infectious BX or chronic Haemophilus influenzae infection had more severe disease. In CF the FEV(1) ("best annual") intercept was 85% predicted with a slope of -2.9% per annum. The choice of reference equation affected the magnitude of the result but not the conclusions.
conclusionChildren with BX have significant airway obstruction which deteriorates over time, regardless of analysis strategy or reference. Effective interventions are needed to prevent significant morbidity and adult mortality.
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Registered trials
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