Evidence map›Paper›PMID 16466936›Full record

ArticleNeuroImage2006

Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease.

Maja Trost, Sherwin Su, Philip Su, Ruoh-Fang Yen, Ham-Min Tseng, Anna Barnes, Yilong Ma, David Eidelberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Article
  7. Article
  8. Preoperative network activity predicts the response to subthalamic DBS for Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Maja TrostCenter for Neurosciences, Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA.
Sherwin Su
Philip Su
Ruoh-Fang Yen
Ham-Min Tseng
Anna Barnes
Yilong Ma
David Eidelberg
National Taiwan University Hospital · TWCenter for Neurosciences · USNorthwell Health · USNeurosciences Institute · US

Funding

PET IN PARKINSONISM: A MULTICENTER COLLABORATIVE STUDYR01NS035069 · NINDS · NORTH SHORE UNIVERSITY HOSPITAL · PI EIDELBERG, DAVID · 1996 to 2003
$3.4M
ASSESSMENT OF DISEASE PROGRESSION IN PARKINSONISMK24NS002101 · NINDS · NORTH SHORE UNIVERSITY HOSPITAL · PI EIDELBERG, DAVID · 1999 to 2003
$407k
NINDS NIH HHS K24 NS002101NINDS NIH HHS K24 NS02101NINDS NIH HHS R01 NS035069NINDS NIH HHS R01 NS 35069
6 · The paper itself

Abstract

Deep brain stimulation of the subthalamic nucleus (STN DBS) has become an accepted tool for the treatment of Parkinson's disease (PD). Although the precise mechanism of action of this intervention is unknown, its effectiveness has been attributed to the modulation of pathological network activity. We examined this notion using positron emission tomography (PET) to quantify stimulation-induced changes in the expression of a PD-related covariance pattern (PDRP) of regional metabolism. These metabolic changes were also compared with those observed in a similar cohort of patients undergoing STN lesioning. We found that PDRP activity declined significantly (P < 0.02) with STN stimulation. The degree of network modulation with DBS did not differ from that measured following lesioning (P = 0.58). Statistical parametric mapping (SPM) revealed that metabolic reductions in the internal globus pallidus (GPi) and caudal midbrain were common to both STN interventions (P < 0.01), although declines in GPi were more pronounced with lesion. By contrast, elevations in posterior parietal metabolism were common to the two procedures, albeit more pronounced with stimulation. These findings indicate that suppression of abnormal network activity is a feature of both STN stimulation and lesioning. Nonetheless, these two interventions may differ metabolically at a regional level.

Indexed as

Deep Brain StimulationImage Processing, Computer-AssistedPositron-Emission TomographyAgedAnalysis of VarianceBlood GlucoseBrain MappingCerebellumCerebral CortexCorpus StriatumEnergy MetabolismFemaleFluorodeoxyglucose F18Globus PallidusGyrus CinguliHumansBlood GlucoseFluorodeoxyglucose F18

Identifiers

PMID16466936
PMCPMC4454374
OpenAlexW2021739815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.