ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Comparative phylogenetic analysis reveals multiple non-imprinted isoforms of opossum Dlk1.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 41 citations in OpenAlex.
- Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns.Journal of diabetes · 2023Review
- Delta-like 1 homolog in Capra hircus: molecular characteristics, expression pattern and phylogeny.Molecular biology reports · 2016Article
- Comparison of splice sites reveals that long noncoding RNAs are evolutionarily well conserved.RNA (New York, N.Y.) · 2015Article
- Genome-wide histone state profiling of fibroblasts from the opossum, Monodelphis domestica, identifies the first marsupial-specific imprinted gene.BMC genomics · 2014Article
- The origin and evolution of genomic imprinting and viviparity in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.BMC genomics · 2012Article
- Review
- A phylogenetic approach to test for evidence of parental conflict or gene duplications associated with protein-encoding imprinted orthologous genes in placental mammals.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Analysis on cDNA sequence, mRNA expression and imprinting status of Dlk1 gene in goats.Molecular biology reports · 2010Article
- The imprinted Phlda2 gene regulates extraembryonic energy stores.Molecular and cellular biology · 2010Article
- Article
- The opossum genome: insights and opportunities from an alternative mammal.Genome research · 2008Review
- The evolution of the DLK1-DIO3 imprinted domain in mammals.PLoS biology · 2008Article
- Environmental epigenomics and disease susceptibility.Nature reviews. Genetics · 2007Review
- Recent assembly of an imprinted domain from non-imprinted components.PLoS genetics · 2006Article
- Imprinting evolution and human health.Mammalian genome : official journal of the International Mammalian Genome SocietyReview
- Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases.Reproductive toxicology (Elmsford, N.Y.)Review
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
Imprinted genes are monoallelically expressed in a parent-of-origin manner and were previously identified in both marsupials and eutherians, but not in monotremes. Phylogenetic comparison of imprinted domains is a powerful tool for investigating the molecular and adaptive evolution of this unique gene regulatory mechanism. Herein, we report that multiple transcripts of Dlk1 (Delta, Drosophila, Homolog-like 1) are expressed in the opossum, but none are imprinted. Thus, we provide the first example of a reciprocally imprinted gene domain in which imprinting evolved in a common ancestor to eutherian rather than therian mammals. Moreover, the reciprocally imprinted Meg3 (Maternally Expressed Gene 3), found downstream of Dlk1 in eutherian mammals, is absent in the opossum. We propose that the Meg3 sequence integrated into the eutherian Dlk1 domain via a LINE-1 element and that Dlk1 became imprinted in eutherian mammals only after this downstream integration. These findings clearly demonstrate that imprinted genes did not all evolve before the divergence of marsupials and eutherians.
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