ArticleNeuroscience and behavioral physiology2006
The role of defensin NP-1 in restoring the functions of an injured nerve trunk.
Article in Neuroscience and behavioral physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Neutrophil biology in injuries and diseases of the central and peripheral nervous systems.Progress in neurobiology · 2023Review
- Intraoperative single administration of neutrophil peptide 1 accelerates the early functional recovery of peripheral nerves after crush injury.Neural regeneration research · 2020Article
- Effects of NP-1 on proliferation, migration, and apoptosis of Schwann cell line RSC96 through the NF-κB signaling pathway.American journal of translational research · 2020Article
- A new strategy to produce a defensin: stable production of mutated NP-1 in nitrate reductase-deficient Chlorella ellipsoidea.PloS one · 2013Article
- Microbial challenge promotes the regenerative process of the injured central nervous system of the medicinal leech by inducing the synthesis of antimicrobial peptides in neurons and microglia.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report presents results from studies on the actions of neutrophil defensin NP-1 on the initial stage of regeneration of the lesioned sciatic nerve in rats. The effects of defensin on the growth rate and functional characteristics of regenerating nerve fibers were assessed by recording total action potentials 21 days after transection and microsurgical suturing of the nerve. These experiments showed that defensin increased the rate of growth of regenerating nerve fibers by 30%: the distance over which nerve spike conductivity was restored in the lesioned nerve increased from 7.2 +/- 1.2 (control) to 10.5 +/- 0.8 mm (experiment) from the suturing site (p < 0.05). In addition, an increase in the excitation conduction rate along the regenerating nerve fibers by 20% compared with control was observed. Overall, the results provide evidence for the positive effects of defensin on restoration of the functions of the lesioned nerve trunk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.