ArticleBritish journal of cancer2006
Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma.
Article in British journal of cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- The Role of MMP8 in Cancer: A Systematic Review.International journal of molecular sciences · 2019Pooled it
- Review
- Proteomic analysis of non-muscle invasive and muscle invasive bladder cancer highlights distinct subgroups with metabolic, matrisomal, and immune hallmarks and emphasizes importance of the stromal compartment.The Journal of pathology · 2025Article
- Insights into the Interplay between the Urinary Microbiome and Bladder Cancer: A Comprehensive Review.Journal of clinical medicine · 2024Review
- Expression and activity of matrilysins - matrix metalloproteinases 7 and 26 in human urinary bladder cancer.Central European journal of urology · 2024Article
- Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer.BMC cancer · 2023Article
- Urological cancer organoids, patients' avatars for precision medicine: past, present and future.Cell & bioscience · 2022Review
- Article
- Dominative role of MMP-14 over MMP-15 in human urinary bladder carcinoma on the basis of its enhanced specific activity.Medicine · 2020Article
- Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture.Cancer science · 2019Article
- High Grade T1 Papillary Urothelial Bladder Cancer Shows Prominent Peritumoral Retraction Clefting.Pathology oncology research : POR · 2018Article
- Positive Correlation between Matrix Metalloproteinases and Epithelial-to-Mesenchymal Transition and its Association with Clinical Outcome in Bladder Cancer Patients.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2018Article
- Decreased Invasion of Urothelial Carcinoma of the Bladder by Inhibition of Matrix-Metalloproteinase 7.Bladder cancer (Amsterdam, Netherlands) · 2018Article
- Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients.Journal of thoracic disease · 2017Article
- Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases.Biomedical reports · 2017Article
- Matrix-metalloproteinases as targets for controlled delivery in cancer: An analysis of upregulation and expression.Journal of controlled release : official journal of the Controlled Release Society · 2017Review
- The interplay of extracellular matrix and microbiome in urothelial bladder cancer.Nature reviews. Urology · 2016Review
- Expression and clinical significance of matrix metalloproteinase-17 and -25 in gastric cancer.Oncology letters · 2015Article
- Urinary high molecular weight matrix metalloproteinases as non-invasive biomarker for detection of bladder cancer.BMC urology · 2013Article
- Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer.BMC urology · 2012Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
The matrix metalloproteinases (MMPs) are endopeptidases which break down the extracellular matrix and regulate cytokine and growth factor activity. Several MMPs have been implicated in the promotion of invasion and metastasis in a broad range of tumours including urothelial carcinoma. In this study, RNA from 132 normal bladder and urothelial carcinoma specimens was profiled for each of the 24 human MMPs, the four endogenous tissue inhibitors of MMPs (TIMPs) and several key growth factors and their receptors using quantitative real time RT-PCR. Laser capture microdissection (LCM) of RNA from 22 tumour and 11 normal frozen sections was performed allowing accurate RNA extraction from either stromal or epithelial compartments. This study confirms the over expression in bladder tumour tissue of well-documented MMPs and highlights a range of MMPs which have not previously been implicated in the development of urothelial cancer. In summary, MMP-2, MT1-MMP and the previously unreported MMP-28 were very highly expressed in tumour samples while MMPs 1, 7, 9, 11, 15, 19 and 23 were highly expressed. There was a significant positive correlation between transcript expression and tumour grade for MMPs 1, 2, 8, 10, 11, 12, 13, 14, 15 and 28 (P < 0.001). At the same confidence interval, TIMP-1 and TIMP-3 also correlated with increasing tumour grade. LCM revealed that most highly expressed MMPs are located primarily within the stromal compartment except MMP-13 which localised to the epithelial compartment. This work forms the basis for further functional studies, which will help to confirm the MMPs as potential diagnostic and therapeutic targets in early bladder cancer.
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