ArticleJournal of neurology, neurosurgery, and psychiatry2006
Prevalence and characteristics of peripheral neuropathy in hepatitis C virus population.
Article in Journal of neurology, neurosurgery, and psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Treatment for cryoglobulinemic and non-cryoglobulinemic peripheral neuropathy associated with hepatitis C virus infection.The Cochrane database of systematic reviews · 2014Pooled it
- Peripheral Neuropathy in Patients with Hepatitis C Infection-Reversibility after HCV Eradication: A Single Center Study.Viruses · 2024Article
- Similarities, differences, and possible interactions between hepatitis E and hepatitis C viruses: Relevance for research and clinical practice.World journal of gastroenterology · 2022Review
- Peripheral neuropathy after viral eradication with direct-acting antivirals in chronic HCV hepatitis: A prospective study.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Severe Guillain-Barré syndrome associated with chronic active hepatitis C and mixed cryoglobulinemia: a case report.BMC infectious diseases · 2019Article
- Article
- Hepatitis C virus and neurological damage.World journal of hepatology · 2016Review
- Mechanisms of distal axonal degeneration in peripheral neuropathies.Neuroscience letters · 2015Review
- Magnitude of peripheral neuropathy in cirrhosis of liver patients from central rural India.Annals of Indian Academy of Neurology · 2014Article
- Clinical, neurophysiological, and skin biopsy findings in peripheral neuropathy associated with hepatitis C virus-related cryoglobulinemia.Journal of neurology · 2014Article
- Neurological complications of hepatitis C infection.Current neurology and neuroscience reports · 2012Review
- Sensory neuropathy in patients with cryoglobulin negative hepatitis-C infection.Journal of neurology · 2011Article
- Hepatitis C seropositivity is not a risk factor for sensory neuropathy among patients with HIV.Neurology · 2010Article
- Emerging issues in neurovirology: new viruses, diagnostic tools, and therapeutics.Neurologic clinics · 2008Review
- Immunohistochemical detection of HCV in nerves and muscles of patients with HCV associated peripheral neuropathy and myositis.International journal of health sciences · 2007Article
- Progressive Brachial Plexus Palsy after Osteosynthesis of an Inveterate Clavicular Fracture.Journal of orthopaedic case reportsArticle
- The Symptom Experience of HIV/HCV-Coinfected Adults.The Journal of the Association of Nurses in AIDS Care : JANACArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the prevalence of peripheral neuropathy (PN) and its correlation with cryoglobulinemia (CG) in an unselected, untreated referral hepatitis C virus (HCV) population. PATIENTS AND
methodsTwo hundred and thirty four patients (120 women and 114 men) with untreated HCV infection were consecutively enrolled by seven Italian centres. Clinical neuropathy was diagnosed when symptoms and signs of peripheral sensory or motor involvement were present. Median, ulnar, peroneal, and sural nerves were explored in all patients and distal symmetric polyneuropathy was diagnosed when all explored nerves or both lower limb nerves were affected. Mononeuropathy and mononeuropathy multiplex were diagnosed when one nerve or two non-contiguous nerves with asymmetrical distribution were affected. Screening for CG was done in 191 unselected patients.
resultsClinical signs of PN were observed in 25 of the 234 patients (10.6%). Electrophysiological PN was found in 36 (15.3%). CG was present in 56/191 patients (29.3%). The prevalence of CG increased significantly with age (p<0.001) and disease duration (p<0.05). PN was present in 12/56 (21%) patients with CG and 18/135 (13%) without CG (p=NS). PN increased significantly with age (p<0.001) and logistic regression analysis confirmed age as the only independent predictor of PN (OR 1.10 for each year; 95% CI 1.04 to 1.15; p<0.001).
conclusionsElectrophysiological examination detected subclinical neuropathy in 11 patients (4.7%). Statistical analysis showed that CG was not a risk factor for PN whereas PN prevalence increased significantly with age.
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