ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Atherosclerosis imaging on the molecular level.
Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Assessment of atherosclerotic plaques in a rabbit model by delayed-phase contrast-enhanced CT angiography: comparison with histopathology.The international journal of cardiovascular imaging · 2012Article
- Design of targeted cardiovascular molecular imaging probes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2010Review
- A rabbit model of atherosclerosis at carotid artery: MRI visualization and histopathological characterization.European radiology · 2008Article
- Present and future of clinical cardiovascular PET imaging in Europe--a position statement by the European Council of Nuclear Cardiology (ECNC).European journal of nuclear medicine and molecular imaging · 2008Review
- Integrating soluble biomarkers and imaging technologies in the identification of vulnerable atherosclerotic patients.Biomarker insights · 2007Article
- Imaging atherosclerosis in the vulnerable patient.European journal of nuclear medicine and molecular imaging · 2007Review
- What are the most useful and trustworthy noninvasive anatomic markers of existing vascular disease?Current cardiology reports · 2006Review
- Molecular imaging will replace perfusion imaging: The impossible dream.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On the basis of clinical observations that acute coronary events often result from rupture of atherosclerotic plaques at sites with no or minor luminal narrowing, the search for techniques by which to identify vulnerable, rupture-prone lesions has developed into a quest for the holy grail of cardiovascular medicine. Vulnerable plaques may show characteristic morphologic features, but they may still differ in their biology and their activity, which ultimately leads to rupture. As a consequence, considerable efforts have been undertaken to identify biologic mechanisms of atherosclerotic lesions by use of molecular-targeted radiolabeled probes. A variety of approaches aiming at plaque inflammation, apoptosis, smooth muscle cell proliferation, extracellular matrix activation, or platelet binding have been introduced. Nevertheless, molecular imaging of atherosclerosis is still a work in progress. Challenges related to the best targeting approach, to translation of animal model results to the clinical setting, to adequate imaging methodology for visualization of coronary artery biology, and to a suitable target patient population will need to be overcome. But the field is steadily moving ahead and getting closer to the ultimate goal of an improved clinical risk assessment through in vivo assessment of vascular biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.