ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Prognostic value of cardiac I-123 metaiodobenzylguanidine imaging in patients with non-insulin-dependent diabetes mellitus.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 79 citations in OpenAlex.
- Effect of intramyocardial bone marrow-derived mononuclear cell injection on cardiac sympathetic innervation in patients with chronic myocardial ischemia.The international journal of cardiovascular imaging · 2014Trial
- Effect of angiotensin-converting enzyme inhibitors on systemic inflammation and myocardial sympathetic innervation in normotensive patients with type 2 diabetes mellitus.Journal of human hypertension · 2008Trial
- The Contribution of Echocardiography to the Diagnosis and Prognosis Stratification of Diabetic Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2025Review
- The neuronal imaging in cardiology: 123I-Biophysical reviews · 2025Review
- Illuminating the Hidden: Standardizing Cardiac MIBG Imaging for Sympathetic Dysfunction.Journal of nuclear medicine technology · 2025Review
- Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis.Communications medicine · 2024Article
- Imaging techniques for the assessment of adverse cardiac remodeling in metabolic syndrome.Heart failure reviews · 2022Review
- Quality and utility of [Annals of nuclear medicine · 2021Article
- Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging.Nature reviews. Cardiology · 2021Review
- How do we establish cardiac sympathetic nervous system imaging withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Myocardial MIBG scintigraphy in genetic Parkinson's disease as a model for Lewy body disorders.European journal of nuclear medicine and molecular imaging · 2019Article
- A Comparative Assessment of Cardiovascular Autonomic Reflex Testing and CardiacInternational journal of endocrinology · 2018Article
- Current Clinical Applications and Next Steps for Cardiac Innervation Imaging.Current cardiology reports · 2017Review
- The Type 2 Diabetic Heart: Its Role in Exercise Intolerance and the Challenge to Find Effective Exercise Interventions.Sports medicine (Auckland, N.Z.) · 2016Review
- ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Individuals with impaired glucose tolerance demonstrate normal cardiac sympathetic innervation using I-123 mIBG scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Cardiac autonomic imaging with SPECT tracers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- Assessment of global cardiac I-123 MIBG uptake and washout using volumetric quantification of SPECT acquisitions.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Cardiovascular imaging in diabetes mellitus.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Review
- Variation of heart-to-mediastinal ratio in (123)I-mIBG cardiac sympathetic imaging: its affecting factors and potential corrections.Current cardiology reports · 2011Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy is a useful tool for diagnosing cardiac autonomic neuropathy (CAN) in non-insulin-dependent diabetes mellitus (NIDDM). However, the long-term prognostic value for cardiac events or mortality in NIDDM has not been clarified. METHODS AND
resultsWe investigated the long-term prognostic value of cardiac MIBG imaging for both cardiac event and mortality owing to a variety of causes of death in NIDDM. 144 NIDDM patients were analyzed retrospectively with the end-points of a cardiac event and various causes of mortality. The heart-to-mediastinum uptake ratio on the delayed image (H/M [d]) was obtained from anterior planar imaging. The mean follow-up period was 7.2+/-3.2 years. Seventeen patients had a cardiac event onset and 7 patients died during observation. During the same observation course, 16 patients died, including some who died of cardiac event. Both multivariate and univariate analyses revealed that decreased H/M (d) (<1.7) was the independent predictor of long-term mortality for a variety of causes of death. Although the value of H/M (d) was not a significant prognostic factor for predicting a cardiac event, CAN, diagnosed by a combination of H/M (d) and coefficient variance of RR interval, was an independent predictor for the cardiac event in NIDDM.
conclusionMIBG myocardial scintigraphy was useful for predicting cardiac events and long-term mortality in NIDDM.
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