ArticleProceedings of the National Academy of Sciences of the United States of America2006
SAD-2 is required for meiotic silencing by unpaired DNA and perinuclear localization of SAD-1 RNA-directed RNA polymerase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 112 citations in OpenAlex.
- An Hsp70 Chaperone Is Involved in Meiotic Silencing by Unpaired DNA.Epigenomes · 2026Article
- ARS2, a Cofactor of CBC, Promotes Meiotic Silencing by Unpaired DNA.Epigenomes · 2026Article
- Inferring fungal cis-regulatory networks from genome sequences via unsupervised and interpretable representation learning.Genetics · 2026Article
- Fungal small RNA: unveiling the breakthroughs and promising applications.Frontiers in fungal biology · 2025Review
- Recent reactivation of a pathogenicity-associated transposable element is associated with major chromosomal rearrangements in a fungal wheat pathogen.Nucleic acids research · 2024Article
- A DEAD-box RNA helicase mediates meiotic silencing by unpaired DNA.G3 (Bethesda, Md.) · 2023Article
- Transcriptional Divergence Underpinning Sexual Development in the Fungal Class Sordariomycetes.mBio · 2022Article
- A-to-I mRNA editing controls spore death induced by a fungal meiotic drive gene in homologous and heterologous expression systems.Genetics · 2022Article
- Meiotic Silencing in DothideomycetousFrontiers in fungal biology · 2022Article
- Genetic Networks That Govern Sexual Reproduction in the Pezizomycotina.Microbiology and molecular biology reviews : MMBR · 2021Review
- Article
- Involvement of RNA granule proteins in meiotic silencing by unpaired DNA.G3 (Bethesda, Md.) · 2021Article
- An introgressed gene causes meiotic drive inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- An NCBP3-Domain Protein Mediates Meiotic Silencing by Unpaired DNA.G3 (Bethesda, Md.) · 2020Article
- Article
- TheG3 (Bethesda, Md.) · 2019Article
- Identification ofGenetics · 2019Article
- It's All in the Genes: The Regulatory Pathways of Sexual Reproduction in Filamentous Ascomycetes.Genes · 2019Review
- Suppressors of Meiotic Silencing by Unpaired DNA.Non-coding RNA · 2019Article
- An RNA Recognition Motif-Containing Protein Functions in Meiotic Silencing by Unpaired DNA.G3 (Bethesda, Md.) · 2017Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
A gene unpaired during the meiotic homolog pairing stage in Neurospora generates a sequence-specific signal that silences the expression of all copies of that gene. This process is called Meiotic Silencing by Unpaired DNA (MSUD). Previously, we have shown that SAD-1, an RNA-directed RNA polymerase (RdRP), is required for MSUD. We isolated a second gene involved in this process, sad-2. Mutated Sad-2 (RIP) alleles, like those of Sad-1, are dominant and suppress MSUD. Crosses homozygous for Sad-2 are blocked at meiotic prophase. SAD-2 colocalizes with SAD-1 in the perinuclear region, where small interfering RNAs have been shown to reside in mammalian cells. A functional sad-2(+) gene is necessary for SAD-1 localization, but the converse is not true. The data suggest that SAD-2 may function to recruit SAD-1 to the perinuclear region, and that the proper localization of SAD-1 is important for its activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.