ArticleProceedings of the National Academy of Sciences of the United States of America2006
Nanomechanics of the subtectorial space caused by electromechanics of cochlear outer hair cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 154 citations in OpenAlex.
- A Newly Identified Role of the Tectorial Membrane in Aminoglycoside Ototoxicity.bioRxiv : the preprint server for biology · 2026Article
- Visualization of relative cochlear motions using high resolution optical coherence microscopy.Hearing research · 2025Article
- The cortilymph wave: Its relation to the traveling wave, auditory-nerve responses, and low-frequency downward glides.Hearing research · 2025Review
- Local cochlear mechanical responses revealed through outer hair cell receptor potential measurements.Biophysical journal · 2024Article
- Optogenetics Reveals Roles for Supporting Cells in Force Transmission to and From Outer Hair Cells in the Mouse Cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Coupling between the Stereocilia of Rat Sensory Inner-Hair-Cell Hair Bundles Is Weak, Shaping Their Sensitivity to Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cochlear motion across the reticular lamina implies that it is not a stiff plate.Scientific reports · 2022Article
- Extensive hearing loss induced by low-frequency noise exposure.Laryngoscope investigative otolaryngology · 2022Article
- Inner hair cell stereocilia displacement in response to focal stimulation of the basilar membrane in the ex vivo gerbil cochlea.Hearing research · 2021Article
- Age-related degradation of tectorial membrane dynamics with loss of CEACAM16.Biophysical journal · 2021Article
- A flexible anatomical set of mechanical models for the organ of Corti.Royal Society open science · 2021Article
- The origin of mechanical harmonic distortion within the organ of Corti in living gerbil cochleae.Communications biology · 2021Article
- Inner hair cell stereocilia are embedded in the tectorial membrane.Nature communications · 2021Article
- MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates CaThe Journal of physiology · 2021Article
- Interactions between Passive and Active Vibrations in the Organ of Corti In Vitro.Biophysical journal · 2020Article
- The Spatial Origins of Cochlear Amplification Assessed by Stimulus-Frequency Otoacoustic Emissions.Biophysical journal · 2020Article
- Unified cochlear model for low- and high-frequency mammalian hearing.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cochlear partition anatomy and motion in humans differ from the classic view of mammals.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Control of hearing sensitivity by tectorial membrane calcium.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stereocilia of the cochlear inner hair cells (IHCs) transduce vibrations into the sensory receptor current. Until now, mechanisms for deflecting these stereocilia have not been identified experimentally. Here, we identify a mechanism by using the electromechanical properties of the soma of the outer hair cell to produce an intracochlear, mechanical force stimulus. It is known that the soma of this cell generates mechanical force in response to a change of its transmembrane potential. In the present experiments, the force was induced by intracochlear electrical stimulation at frequencies that covered the entire functionally relevant range of 50 kHz. Vibration responses were measured in the transverse direction with a laser Doppler vibrometer. For frequencies up to approximately 3 kHz in the first three turns of the guinea-pig cochlea, the apical surface of the IHC and the opposing surface of the tectorial membrane were found to vibrate with similar amplitudes but opposite phases. At high frequencies, there was little relative motion between these surfaces in the transverse direction. The counterphasic motion up to approximately 3 kHz results in a pulsatile motion of the fluid surrounding the stereocilia of the IHCs. Based on physical principles of fluid flow between narrowly spaced elastic plates, we show that radial fluid motion is amplified relative to transverse membrane motion and that the radial motion is capable of bending the stereocilia. In conclusion, for frequencies up to at least 3 kHz, there appears to be direct fluid coupling between outer hair cells and IHCs.
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