ArticleJournal of leukocyte biology2006
Chemokine- and adhesion-dependent survival of neutrophils after transmigration through cytokine-stimulated endothelium.
Article in Journal of leukocyte biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation.Journal of translational autoimmunity · 2025Article
- Hyaluronan and Its Receptors: Key Mediators of Immune Cell Entry and Trafficking in the Lymphatic System.Cells · 2021Review
- Photobiomodulation and Antiviral Photodynamic Therapy in COVID-19 Management.Advances in experimental medicine and biology · 2021Article
- Neutrophil trafficking to lymphoid tissues: physiological and pathological implications.The Journal of pathology · 2019Review
- Triggering the Resolution of Immune Mediated Inflammatory Diseases: Can Targeting Leukocyte Migration Be the Answer?Frontiers in pharmacology · 2019Article
- Leukocyte trafficking between stromal compartments: lessons from rheumatoid arthritis.Nature reviews. Rheumatology · 2018Review
- Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation.Scientific reports · 2017Article
- Multiple Phenotypic Changes Define Neutrophil Priming.Frontiers in cellular and infection microbiology · 2017Review
- A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction.Journal of leukocyte biology · 2016Article
- EphrinA4 plays a critical role in α4 and αL mediated survival of human CLL cells during extravasation.Oncotarget · 2016Article
- The roles of integrins in function of human neutrophils after their migration through endothelium into interstitial matrix.PloS one · 2015Article
- Anti-inflammatory peptides from cardiac progenitors ameliorate dysfunction after myocardial infarction.Journal of the American Heart Association · 2014Article
- Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.Open biology · 2012Review
- Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium.Immunology · 2010Article
- The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.Cell communication and signaling : CCS · 2010Article
- Nitric oxide attenuates vascular endothelial cadherin-mediated vascular integrity in human chronic inflammation.Clinical and experimental immunology · 2008Article
- Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases.American journal of physiology. Heart and circulatory physiology · 2008Review
- Immune interactions in hepatic fibrosis.Clinics in liver disease · 2008Review
- Fc receptor engagement mediates differentiation of cardiac fibroblast precursor cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
We examined the fate of neutrophils following transmigration through an endothelial monolayer cultured on "Transwell" membrane filters. Treatment of human umbilical vein endothelial cells (HUVEC) with increasing doses of tumor necrosis factor-alpha increased the efficiency of transmigration and markedly reduced apoptosis among the transmigrated neutrophils in a dose-dependent manner. Apoptosis was also inhibited after transmigration of neutrophils through HUVEC stimulated with interleukin (IL)-1beta but not so effectively after chemotaxis through unstimulated HUVEC driven by IL-8 added below the filter. Inhibition of beta2-integrin binding after transmigration or coating the lower chamber with a nonadhesive polymer (polyhydroxyl-ethyl-methacrylate) abrogated neutrophil survival. Although integrin engagement during migration itself was not essential to inhibit apoptosis, activation of neutrophils through CXC chemokine receptors was necessary. Quite brief exposure to the HUVEC (30-120 min) was effective in reducing subsequent apoptosis, although if coincubation with the HUVEC were prolonged, neutrophil apoptosis was reduced further. Neutralization of granulocyte macrophage-colony stimulating factor inhibited this additional effect. Thus, a complex interplay between migration- and activation-dependent signals and adhesive interaction in tissue may combine to effectively prolong the survival of neutrophils recruited during inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.