ArticleApplied and environmental microbiology2006
A quorum-quenching approach to investigate the conservation of quorum-sensing-regulated functions within the Burkholderia cepacia complex.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Lactonase-mediated inhibition of quorum sensing largely alters phenotypes, proteome, and antimicrobial activities inFrontiers in cellular and infection microbiology · 2023Article
- A Bacterial Isolate Capable of Quenching Both Diffusible Signal Factor- andJournal of agricultural and food chemistry · 2022Article
- A novel bacterial strainFrontiers in plant science · 2022Article
- Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective.Frontiers in pharmacology · 2018Review
- Quorum Sensing and Spoilage Potential of Psychrotrophic Enterobacteriaceae Isolated from Milk.BioMed research international · 2018Article
- Effects of an inducible aiiA gene on disease resistance in Eucalyptus urophylla × Eucalyptus grandis.Transgenic research · 2016Article
- Article
- Stenotrophomonas maltophilia responds to exogenous AHL signals through the LuxR solo SmoR (Smlt1839).Frontiers in cellular and infection microbiology · 2015Article
- Marine-derived quorum-sensing inhibitory activities enhance the antibacterial efficacy of tobramycin against Pseudomonas aeruginosa.Marine drugs · 2014Article
- Lack of AHL-based quorum sensing in Pseudomonas fluorescens isolated from milk.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Quorum quenching mediated approaches for control of membrane biofouling.International journal of biological sciences · 2014Review
- N-acyl homoserine lactone-mediated quorum sensing with special reference to use of quorum quenching bacteria in membrane biofouling control.BioMed research international · 2014Review
- Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection.International journal of molecular sciences · 2013Review
- Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.Virulence · 2013Review
- Identification of quorum sensing-controlled genes in Burkholderia ambifaria.MicrobiologyOpen · 2013Article
- Evaluating the pathogenic potential of environmental Escherichia coli by using the Caenorhabditis elegans infection model.Applied and environmental microbiology · 2013Article
- Identification of functions linking quorum sensing with biofilm formation in Burkholderia cenocepacia H111.MicrobiologyOpen · 2012Article
- Orally administered thermostable N-acyl homoserine lactonase from Bacillus sp. strain AI96 attenuates Aeromonas hydrophila infection in zebrafish.Applied and environmental microbiology · 2012Article
- Characterisation of two quorum sensing systems in the endophytic Serratia plymuthica strain G3: differential control of motility and biofilm formation according to life-style.BMC microbiology · 2011Article
- Interkingdom signaling between pathogenic bacteria and Caenorhabditis elegans.Trends in microbiology · 2010Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taxonomic studies of the past few years have shown that the Burkholderia cepacia complex, a heterogeneous group of B. cepacia-like organisms, consists of at least nine species. B. cepacia complex strains are ubiquitously distributed in nature and have been used for biocontrol, bioremediation, and plant growth promotion purposes. At the same time, B. cepacia complex strains have emerged as important opportunistic pathogens of humans, particularly those with cystic fibrosis. All B. cepacia complex species investigated thus far use quorum-sensing (QS) systems that rely on N-acylhomoserine lactone (AHL) signal molecules to express certain functions, including the production of extracellular proteases, swarming motility, biofilm formation, and pathogenicity, in a population-density-dependent manner. In this study we constructed a broad-host-range plasmid that allowed the heterologous expression of the Bacillus sp. strain 240B1 AiiA lactonase, which hydrolyzes the lactone ring of various AHL signal molecules, in all described B. cepacia complex species. We show that expression of AiiA abolished or greatly reduced the accumulation of AHL molecules in the culture supernatants of all tested B. cepacia complex strains. Phenotypic characterization of wild-type and transgenic strains revealed that protease production, swarming motility, biofilm formation, and Caenorhabditis elegans killing efficiency was regulated by AHL in the large majority of strains investigated.
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