ArticleApplied and environmental microbiology2006
First insights into the evolution of Streptococcus uberis: a multilocus sequence typing scheme that enables investigation of its population biology.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Streptococcal infection and its antimicrobial resistance profile associated with bovine mastitis in Ethiopia: a systematic review and meta-analysis.Frontiers in veterinary science · 2025Pooled it
- Molecular and phenotypic characterization ofMicrobiology spectrum · 2026Article
- Discovery of glycerol phosphate and an immunogenic glycan motif in rhamnose-rich polysaccharides of Streptococcus uberis.Veterinary research · 2025Article
- Establishment of a Multilocus Sequence Typing Scheme forAnnals of laboratory medicine · 2025Article
- Antimicrobial resistance patterns of Streptococcus uberis isolates from bovine milk in Chiba prefecture, Japan: association between multidrug resistance and clonal complex 996.The Journal of veterinary medical science · 2024Article
- A core genome multi-locus sequence typing scheme forMicrobial genomics · 2024Article
- Survey of Genotype Diversity, Virulence, and Antimicrobial Resistance Genes in Mastitis-CausingPathogens (Basel, Switzerland) · 2023Article
- Multilocus Sequence Genotype Heterogeneity inAnimals : an open access journal from MDPI · 2022Article
- Genomic surveillance reveals antibiotic resistance gene transmission via phage recombinases within sheep mastitis-associated Streptococcus uberis.BMC veterinary research · 2022Article
- Comparison of Virulence Patterns BetweenFrontiers in veterinary science · 2022Article
- Molecular Typing and Antimicrobial Susceptibility Profiles ofPathogens (Basel, Switzerland) · 2021Article
- Sequence characterisation and novel insights into bovine mastitis-associated Streptococcus uberis in dairy herds.Scientific reports · 2021Article
- Impact of yeast and lactic acid bacteria on mastitis and milk microbiota composition of dairy cows.AMB Express · 2020Article
- PCR-Based Direct Detection ofVeterinary medicine international · 2020Article
- Molecular variability ofCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2019Article
- Sequence Types and Antimicrobial Resistance Profiles ofFrontiers in veterinary science · 2019Article
- Evidence of the genetic diversity and clonal population structure of Oenococcus oeni strains isolated from different wine-making regions of China.Journal of microbiology (Seoul, Korea) · 2018Article
- Application of a Dot Blot Hybridization Platform to AssessFrontiers in microbiology · 2017Article
- Phylogenetic, epidemiological and functional analyses of the Streptococcus bovis/Streptococcus equinus complex through an overarching MLST scheme.BMC microbiology · 2016Article
- Molecular Epidemiology of Streptococcus uberis Clinical Mastitis in Dairy Herds: Strain Heterogeneity and Transmission.Journal of clinical microbiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intramammary infection with Streptococcus uberis is a common cause of bovine mastitis throughout the world. Several procedures to differentiate S. uberis isolates have been proposed. However, all are prone to interlaboratory variation, and none is suitable for the description of the population structure. We describe here the development of a multilocus sequence typing (MLST) scheme for S. uberis to help address these issues. The sequences of seven housekeeping gene fragments from each of 160 United Kingdom milk isolates of S. uberis were determined. Between 5 and 17 alleles were obtained per locus, giving the potential to discriminate between 1.3 x 10(7) sequence types. In this study, 57 sequence types (STs) were identified. Statistical comparisons between the maximum-likelihood trees constructed by using the seven housekeeping gene fragments showed that the congruence was no better than that between each tree and trees of random topology, indicating there had been significant recombination within these loci. The population contained one major lineage (designated the ST-5 complex). This dominated the population, containing 24 STs and representing 112 isolates. The other 33 STs were not assigned to any clonal complex. All of the isolates in the ST-5 lineage carried hasA, a gene that is essential for capsule production. There was no clear association between ST or clonal complex and disease. The S. uberis MLST system offers researchers a valuable tool that allows further investigation of the population biology of this organism and insights into the epidemiology of this disease on a global scale.
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