ArticleApplied and environmental microbiology2006
Natural transformation-mediated transfer of erythromycin resistance in Campylobacter coli strains from turkeys and swine.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Impact of Veterinary Feed Directive Rules Changes on the Prevalence of Antibiotic Resistance Bacteria Isolated from Cecal Samples of Food-Producing Animals at US Slaughterhouses.Pathogens (Basel, Switzerland) · 2024Article
- Genomic Analysis Points to Multiple Genetic Mechanisms for Non-TransformableMicroorganisms · 2024Article
- Differences in the Propensity of Different Antimicrobial Resistance Determinants to Be Disseminated via Transformation inMicroorganisms · 2022Article
- Natural Transformation as a Mechanism of Horizontal Gene Transfer inPathogens (Basel, Switzerland) · 2021Article
- Natural Horizontal Gene Transfer of Antimicrobial Resistance Genes inFrontiers in microbiology · 2021Article
- The Current State of Macrolide Resistance in Campylobacter spp.: Trends and Impacts of Resistance Mechanisms.Applied and environmental microbiology · 2017Review
- Potential DNA binding and nuclease functions of ComEC domains characterized in silico.Proteins · 2016Article
- The Risk of Some Veterinary Antimicrobial Agents on Public Health Associated with Antimicrobial Resistance and their Molecular Basis.Frontiers in microbiology · 2016Review
- Absence of intervening sequences and point mutations in the V domain within 23S rRNA in Campylobacter lari isolates.Folia microbiologica · 2013Article
- Antimicrobial resistance mechanisms among Campylobacter.BioMed research international · 2013Review
- Identification of a novel genomic island conferring resistance to multiple aminoglycoside antibiotics in Campylobacter coli.Antimicrobial agents and chemotherapy · 2012Article
- A longitudinal 6-year study of the molecular epidemiology of clinical campylobacter isolates in Oxfordshire, United kingdom.Journal of clinical microbiology · 2012Article
- Differences in methylation at GATC sites in genomic DNA of Campylobacter coli from turkeys and swine.Applied and environmental microbiology · 2010Article
- Caught in the act: in vivo development of macrolide resistance to Campylobacter jejuni infection.Journal of clinical microbiology · 2010Article
- Antibiotic resistance in Campylobacter: emergence, transmission and persistence.Future microbiology · 2009Review
- Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni.Antimicrobial agents and chemotherapy · 2008Article
- Differential effects of temperature on natural transformation to erythromycin and nalidixic acid resistance in Campylobacter coli.Applied and environmental microbiology · 2008Article
- Role of Cj1211 in natural transformation and transfer of antibiotic resistance determinants in Campylobacter jejuni.Antimicrobial agents and chemotherapy · 2008Article
- Cj0011c, a periplasmic single- and double-stranded DNA-binding protein, contributes to natural transformation in Campylobacter jejuni.Journal of bacteriology · 2007Article
- Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens.Antimicrobial agents and chemotherapy · 2007Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythromycin resistance in Campylobacter coli from meat animals is frequently encountered and could represent a substantial barrier to antibiotic treatment of human infections. Erythromycin resistance in this organism has been associated with a point mutation (A2075G) in the 23S rRNA gene. However, the mechanisms responsible for possible dissemination of erythromycin resistance in C. coli remain poorly understood. In this study, we investigated transformation-mediated acquisition of erythromycin resistance by genotypically diverse C. coli strains from turkeys and swine, with total genomic DNA from erythromycin-resistant C. coli of either turkey or swine origin used as a donor. Overall, transformation to erythromycin resistance was significantly more frequent in C. coli strains from turkeys than in swine-derived strains (P < 0.01). The frequency of transformation to erythromycin resistance was 10(-5) to 10(-6) for turkey-derived strains but 10(-7) or less for C. coli from swine. Transformants harbored the point mutation A2075G in the 23S rRNA gene, as did the erythromycin-resistant strains used as DNA donors. Erythromycin resistance was stable in transformants following serial transfers in the absence of the antibiotic, and most transformants had high MICs (>256 microg/ml), as did the C. coli donor strains. In contrast to the results obtained with transformation, spontaneous mutants had relatively low erythromycin MICs (32 to 64 microg/ml) and lacked the A2075G mutation in the 23S rRNA gene. These findings suggest that natural transformation has the potential to contribute to the dissemination of high-level resistance to erythromycin among C. coli strains colonizing meat animals.
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