ArticleBiophysical journal2006
Statistical evaluation of ion-channel gating models based on distributions of log-likelihood ratios.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
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- Estimating kinetic mechanisms with prior knowledge II: Behavioral constraints and numerical tests.The Journal of general physiology · 2018Article
- Estimating kinetic mechanisms with prior knowledge I: Linear parameter constraints.The Journal of general physiology · 2018Article
- Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states.Mathematical biosciences · 2016Article
- Analyzing single-molecule time series via nonparametric Bayesian inference.Biophysical journal · 2015Article
- Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating.The Journal of general physiology · 2014Article
- Conformational changes in the catalytically inactive nucleotide-binding site of CFTR.The Journal of general physiology · 2013Article
- Efficient maximum likelihood estimation of kinetic rate constants from macroscopic currents.PloS one · 2011Article
- Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Inverse effects on gating and modulation caused by a mutation in the M2-M3 Linker of the GABA(A) receptor gamma subunit.Molecular pharmacology · 2009Article
- Real-time kinetic modeling of voltage-gated ion channels using dynamic clamp.Biophysical journal · 2008Article
- The N-terminal transmembrane domain (TMD0) and a cytosolic linker (L0) of sulphonylurea receptor define the unique intrinsic gating of KATP channels.The Journal of physiology · 2006Article
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1 author.
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Abstract
The distributions of log-likelihood ratios (DeltaLL) obtained from fitting ion-channel dwell-time distributions with nested pairs of gating models (Xi, full model; Xi(R), submodel) were studied both theoretically and using simulated data. When Xi is true, DeltaLL is asymptotically normally distributed with predictable mean and variance that increase linearly with data length (n). When Xi(R) is true and corresponds to a distinct point in full parameter space, DeltaLL is Gamma-distributed (2DeltaLL is chi-square). However, when data generated by an l-component multiexponential distribution are fitted by l+1 components, Xi(R) corresponds to an infinite set of points in parameter space. The distribution of DeltaLL is a mixture of two components, one identically zero, the other approximated by a Gamma-distribution. This empirical distribution of DeltaLL, assuming Xi(R), allows construction of a valid log-likelihood ratio test. The log-likelihood ratio test, the Akaike information criterion, and the Schwarz criterion all produce asymmetrical Type I and II errors and inefficiently recognize Xi, when true, from short datasets. A new decision strategy, which considers both the parameter estimates and DeltaLL, yields more symmetrical errors and a larger discrimination power for small n. These observations are explained by the distributions of DeltaLL when Xi or Xi(R) is true.
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