ArticleBiophysical journal2006
Phase behavior of lipid monolayers containing DPPC and cholesterol analogs.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Using diffusion-induced growth instabilities to measure line tension at liquid condensed-liquid expanded domain boundaries.Journal of colloid and interface science · 2026Article
- Lipid Droplet Surface Promotes 3D Morphological Evolution of Non-Rhomboidal Cholesterol Crystals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Sterol-lipids enable large-scale, liquid-liquid phase separation in bilayer membranes of only two components.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective.International journal of molecular sciences · 2024Review
- Closed-loop fluid-fluid immiscibility in binary lipid-sterol membranes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Role of Cholesterol and its Biosynthetic Precursors on Membrane Organization and Dynamics: A Fluorescence Approach.The Journal of membrane biology · 2023Article
- Dilatational and shear rheology of soluble and insoluble monolayers with a Langmuir trough.Journal of colloid and interface science · 2023Article
- Effect of Silica Microparticles on Interactions in Mono- and Multicomponent Membranes.International journal of molecular sciences · 2022Article
- Review
- Bilayer aggregate microstructure determines viscoelasticity of lung surfactant suspensions.Soft matter · 2021Article
- Article
- Cholesterol Regulates the Incorporation and Catalytic Activity of Tissue-Nonspecific Alkaline Phosphatase in DPPC Monolayers.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Cholesterol enhances influenza binding avidity by controlling nanoscale receptor clustering.Chemical science · 2018Article
- Influenza viral membrane fusion is sensitive to sterol concentration but surprisingly robust to sterol chemical identity.Scientific reports · 2016Article
- Visualizing monolayers with a water-soluble fluorophore to quantify adsorption, desorption, and the double layer.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases.PloS one · 2013Article
- Effect of ring-substituted oxysterols on the phase behavior of dipalmitoylphosphatidylcholine membranes.European biophysics journal : EBJ · 2012Article
- Side-chain oxysterols: from cells to membranes to molecules.Biochimica et biophysica acta · 2012Review
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigate the miscibility phase behavior of lipid monolayers containing a wide variety of sterols. Six of the sterols satisfy a definition from an earlier study of "membrane-active sterols" in bilayers (cholesterol, epicholesterol, lathosterol, dihydrocholesterol, ergosterol, and desmosterol), and six do not (25-hydroxycholesterol, lanosterol, androstenolone, coprostanol, cholestane, and cholestenone). We find that monolayers containing dipalmitoyl phosphatidylcholine mixed with membrane-active sterols generally produce phase diagrams containing two distinct regions of immiscible liquid phases, whereas those with membrane-inactive sterols generally do not. This observation establishes a correlation between lipid monolayers and bilayers. It also demonstrates that the ability to form two regions of immiscibility in monolayers is not one of the biophysical attributes that explains cholesterol's predominance in animal cell membranes. Furthermore, we find unusual phase behavior for dipalmitoyl phosphatidylcholine monolayers containing 25-hydroxycholesterol, which produce both an upper and a lower miscibility transition. The lower transition correlates with a sharp change of slope in the pressure-area isotherm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.