Evidence map›Paper›PMID 16460570›Full record

ArticleJournal of carcinogenesis2006

Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats.

Gayle A Orner, Bill D Roebuck, Roderick H Dashwood, George S Bailey

Open access · goldAbstract read
In one paragraph

Article in Journal of carcinogenesis, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gayle A OrnerLinus Pauling Institute, Oregon State University, Corvallis, OR, USA. gayle.orner@orst.edu.
Bill D Roebuck
Roderick H Dashwood
George S Bailey
Oregon State University · USDartmouth College · US

Funding

Reducing Susceptibility to Environmental Stress Throughout the Life SpanP30ES000210 · NIEHS · OREGON STATE UNIVERSITY · PI BECKMAN, JOSEPH S · 1985 to 2015
$21.4M
Transplacental Chemoprevention of Lung Tumors and LymphomasP01CA090890 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DASHWOOD, RODERICK H · 2003 to 2014
$14.2M
PILOT--EFFECT OF TEMPERATURE ACCLIMATION ON PEROXISOMES OF TROUTP30ES003850 · NIEHS · OREGON STATE UNIVERSITY · PI WILLIAMS, DAVID E. · 1988 to 2006
$2.8M
Modulation of Colon Carcinogenesis by ChlorophyllinR01CA065525 · NCI · OREGON STATE UNIVERSITY · PI DASHWOOD, RODERICK H · 2004 to 2008
$1.5M
Combined effects of tea plus NSAIDS towards colon cancerR21CA100608 · NCI · OREGON STATE UNIVERSITY · PI ORNER, GAYLE A · 2003 to 2004
$419k
MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLINR29CA065525 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI DASHWOOD, RODERICK H · 1996 to 2000
$99k
NCI NIH HHS P01 CA090890NCI NIH HHS R01 CA065525NCI NIH HHS R21 CA100608NCI NIH HHS R29 CA065525NIEHS NIH HHS P30 ES000210NIEHS NIH HHS P30 ES003850
6 · The paper itself

Abstract

Chlorophyllin (CHL) is a promising chemopreventive agent believed to block cancer primarily by inhibiting carcinogen uptake through the formation of molecular complexes with the carcinogens. However, recent studies suggest that CHL may have additional biological effects particularly when given after the period of carcinogen treatment. This study examines the post-initiation effects of CHL towards aflatoxin B1 (AFB1)-induced preneoplastic foci of the liver and colon. The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB1-induced foci of the liver and colons of rats.

Identifiers

PMID16460570
PMCPMC1373623
OpenAlexW2051007717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.