ReviewAnnual review of physiology2006
Insights on TRP channels from in vivo studies in Drosophila.
Review in Annual review of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 76 citations in OpenAlex.
- Updates in the Treatment of Rosacea with γ-Aminobutyric Acid Derivatives.Clinical, cosmetic and investigational dermatology · 2025Review
- Parasite manipulation of host phenotypes inferred from transcriptional analyses in a trematode-amphipod system.Molecular ecology · 2023Article
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- The Role of Membrane Lipids in Light-Activation ofBiomolecules · 2022Review
- The Calcium Channel α2δ1 Subunit: Interactional Targets in Primary Sensory Neurons and Role in Neuropathic Pain.Frontiers in cellular neuroscience · 2021Review
- Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach.Molecules (Basel, Switzerland) · 2018Article
- Article
- CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells.Journal of cell science · 2016Article
- Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo.Journal of cell science · 2013Article
- Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel.The Journal of biological chemistry · 2012Article
- A self-limiting regulation of vasoconstrictor-activated TRPC3/C6/C7 channels coupled to PI(4,5)P₂-diacylglycerol signalling.The Journal of physiology · 2012Article
- Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension.Journal of signal transduction · 2012Article
- Retinal degeneration in the fly.Advances in experimental medicine and biology · 2012Review
- XPORT-dependent transport of TRP and rhodopsin.Neuron · 2011Article
- Translocation of the Drosophila transient receptor potential-like (TRPL) channel requires both the N- and C-terminal regions together with sustained Ca2+ entry.The Journal of biological chemistry · 2011Article
- Cellular functions of transient receptor potential channels.The international journal of biochemistry & cell biology · 2010Review
- Why Drosophila to study phototransduction?Journal of neurogenetics · 2010Article
- Light-dependent phosphorylation of the drosophila transient receptor potential ion channel.The Journal of biological chemistry · 2010Article
- Lipid second messengers and related enzymes in vertebrate rod outer segments.Journal of lipid research · 2010Review
- Molecular and cellular designs of insect taste receptor system.Frontiers in cellular neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Transient receptor potential (TRP) channels mediate responses in a large variety of signaling mechanisms. Most studies on mammalian TRP channels rely on heterologous expression, but their relevance to in vivo tissues is not entirely clear. In contrast, Drosophila TRP and TRP-like (TRPL) channels allow direct analyses of in vivo function. In Drosophila photoreceptors, activation of TRP and TRPL is mediated via the phosphoinositide cascade, with both Ca2+ and diacylglycerol (DAG) essential for generating the light response. In tissue culture cells, TRPL channels are constitutively active, and lipid second messengers greatly facilitate this activity. Inhibition of phospholipase C (PLC) completely blocks lipid activation of TRPL, suggesting that lipid activation is mediated via PLC. In vivo studies in mutant Drosophila also reveal an acute requirement for lipid-producing enzyme, which may regulate PLC activity. Thus, PLC and its downstream second messengers, Ca2+ and DAG, constitute critical mediators of TRP/TRPL gating in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.