ArticleBiochemistry2006
Hybridization of complementary and homologous peptide nucleic acid oligomers to a guanine quadruplex-forming RNA.
Article in Biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues.Nucleic acids research · 2021Review
- Homologous PNA Hybridization to Noncanonical DNA G-Quadruplexes.Biochemistry · 2016Article
- Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes.Bioorganic & medicinal chemistry letters · 2015Article
- Strand invasion of DNA quadruplexes by PNA: comparison of homologous and complementary hybridization.Chembiochem : a European journal of chemical biology · 2013Article
- Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.Chemical communications (Cambridge, England) · 2011Article
- Noncovalent binding and fluorogenic response of cyanine dyes to DNA homoquadruplex and PNA-DNA heteroquadruplex structures.Artificial DNA, PNA & XNA · 2011Article
- Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions.Chemical communications (Cambridge, England) · 2010Article
- Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity.Journal of the American Chemical Society · 2009Article
- Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine.Bioorganic & medicinal chemistry letters · 2009Article
- First International Meeting on Quadruplex DNA.ACS chemical biology · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Peptide nucleic acid (PNA) oligomers targeted to guanine quadruplex-forming RNAs can be designed in two different ways. First, complementary cytosine-rich PNAs can hybridize by the formation of Watson-Crick base pairs, resulting in hybrid PNA-RNA duplexes. Second, guanine-rich homologous PNAs can hybridize by the formation of G tetrads, resulting in hybrid PNA-RNA quadruplexes. UV thermal denaturation, circular dichroism, and fluorescence spectroscopy experiments were used to compare these two recognition modes and revealed 1:1 duplex formation for the complementary PNA and 2:1 (PNA2-RNA) quadruplex formation for the homologous PNA. Both hybrids were very stable, and hybridization was observed at low nanomolar concentrations. Hybrid quadruplex formation was equally efficient regardless of the PNA strand polarity, indicating a lack of interaction between the loop nucleobases on the PNA and RNA strands. The implications of this finding on sequence specificity as well as methods to improve affinity are also discussed.
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Registered trials
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