ArticleCancer letters2006
Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer.
Article in Cancer letters, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Decitabine enhances the tumoricidal potential of TRAIL via the epigenetic regulation of death receptor 4 in gastric cancer.Journal of gastrointestinal oncology · 2022Article
- STAT3 and STAT5 Activation in Solid Cancers.Cancers · 2019Review
- SOCS1 inhibits migration and invasion of prostate cancer cells, attenuates tumor growth and modulates the tumor stroma.Prostate cancer and prostatic diseases · 2017Article
- Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer.BMC cancer · 2017Article
- BMP pathway suppression is an early event in inflammation-driven colon neoplasmatogenesis of uPA-deficient mice.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Aberrant gene promoter methylation of p16, FHIT, CRBP1, WWOX, and DLC-1 in Epstein-Barr virus-associated gastric carcinomas.Medical oncology (Northwood, London, England) · 2015Article
- Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.The Journal of biological chemistry · 2014Article
- Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation.Experimental biology and medicine (Maywood, N.J.) · 2014Article
- Expression of SOCSs in human prostate cancer and their association in prognosis.Molecular and cellular biochemistry · 2013Article
- Article
- GATA4 and DcR1 methylation in glioblastomas.Diagnostic pathology · 2013Article
- Cisplatin-induced apoptosis and development of resistance are transcriptionally distinct processes.Cell cycle (Georgetown, Tex.) · 2012Article
- Reprimo (RPRM) is a novel tumor suppressor in pituitary tumors and regulates survival, proliferation, and tumorigenicity.Endocrinology · 2012Article
- TGF-β mediated DNA methylation in prostate cancer.Translational andrology and urology · 2012Article
- Article
- Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease: a pilot study.PloS one · 2012Article
- DNA methylation in promoter region as biomarkers in prostate cancer.Methods in molecular biology (Clifton, N.J.) · 2012Article
- CpG-island methylation study of liver fluke-related cholangiocarcinoma.British journal of cancer · 2011Article
- Global reactivation of epigenetically silenced genes in prostate cancer.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Reactivation of death receptor 4 (DR4) expression sensitizes medulloblastoma cell lines to TRAIL.Journal of neuro-oncology · 2009Article
Corrections and comments
- Retraction · 2015-04-28Duplication of/in Image · Investigation by Company/Institution · Manipulation of Images ·
- Commented on by
- Commented on by
- Retracted
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated aberrant methylation in 101 prostate cancers(PCa) and 32 histologically normal prostate tissues. We focused on genes largely in the apoptotic pathway. Methylation frequencies of the genes were Reprimo, 54%; TMS1, 47%; DcR1, 45%; RRAD, 37%; DcR2, 37%; CRBP1, 34%; HPP1, 32%; RIZ1, 31%; DRM/Gremlin, 21%; SOCS1, 20%; DR4, 5%; DR5, 1%. Methylation of Reprimo and TMS1 correlate with preoperative serum prostate-specific antigen. Methylation of TMS1, DcR1, DcR2, and CRBP1 correlate with Gleason score. Methylation of TMS1 and unmethylation of both DcR1 and DcR2 correlate with poorer disease free survival by univariate and multivariate analyses. Our data suggest that methylation of multiple genes may be involved in pathogenesis and correlate with prognosis of PCa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.