ArticleMolecular and cellular neurosciences2005
Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions.
Article in Molecular and cellular neurosciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- The emerging role of human transmembrane RGD-based counter-receptors of integrins in health and disease.Cellular & molecular biology letters · 2025Review
- Glia trigger endocytic clearance of axonal proteins to promote rodent myelination.Developmental cell · 2024Article
- L1cam-mediated developmental processes of the nervous system are differentially regulated by proteolytic processing.Scientific reports · 2019Article
- Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System.Cellular and molecular gastroenterology and hepatology · 2018Article
- L1cam is crucial for cell locomotion and terminal translocation of the Soma in radial migration during murine corticogenesis.PloS one · 2014Article
- Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex.Journal of neuroscience research · 2013Article
- L1 cell adhesion molecule as a potential therapeutic target in murine models of endometriosis using a monoclonal antibody approach.PloS one · 2013Article
- Article
- L1 stimulation of human glioma cell motility correlates with FAK activation.Journal of neuro-oncology · 2011Article
- Integrins are necessary for the development and maintenance of the glial layers in the Drosophila peripheral nerve.Development (Cambridge, England) · 2011Article
- A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice.Neurogenetics · 2010Article
- An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Article
- Spatiotemporal expression of PSD-95 and nNOS after rat sciatic nerve injury.Neurochemical research · 2008Article
Corrections and comments
- Republished from
Authors and funding
6 authors.
Funding
Abstract
The cell adhesion molecule L1 is important for peripheral nerve development. Mice lacking the 6th Ig domain of L1 (L1-6D mice) lose L1 homophilic binding and RGD dependent LI-integrin binding [Itoh,K., Cheng, L., Kamei, Y., Fushiki, S., Kamiguchi, H., Gutwein, P.,Stoeck, A., Arnold, B., Altevogt, P., Lemmon, V., 2004. Brain development in mice lacking Li-L homophilic adhesion. J. Cell Biol.165, 145-154]. We examined the ultrastructure of sciatic nerves from L1-6D at postnatal day 7 and 8 weeks. Unmyelinated axons frequently detached at the edge of Schwann cells, and naked axons were observed. Myelin was thinner in L1-6D and abnormal, multiple axons wrapped in a single myelin sheath were routinely observed. Previous work has shown that L1 on axons interacts with a heterophilic binding partner on Schwann cells to facilitate normal peripheral nerve formation. Taken together, it is likely that L1 on axons binds integrins on Schwann cells, resulting in interactions between axons and Schwann cells that are essential for ensheathment and myelination.
Indexed as
Identifiers
16456929What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.