Evidence map›Paper›PMID 16456724›Full record

ReviewThe Journal of membrane biology2005

The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation of cardiac ion channels as a potential mechanism.

Y-F Xiao, D C Sigg, A Leaf

Abstract readReview
PubMed Publisher
In one paragraph

Review in The Journal of membrane biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
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  12. n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease: Principles, Practices, Pitfalls, and Promises - A Contemporary Review.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017
    Review
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  19. Omega-3 PUFAs and atrial fibrillation: have we made up our mind yet?Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2013
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Y-F XiaoCardiac Rhythm Management, Medtronic Inc., Minneapolis, MN 55432, USA. yong-fu.xiao@medtronic.com
D C Sigg
A Leaf
Medtronic (United States) · USMassachusetts General Hospital · US

Funding

HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIASR01HL062284 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEAF, ALEXANDER · 1999 to 2001
$490k
MECHANISMS OF DISEASE PREVENTION OF N-3 FATTY ACIDSR01DK038165 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LEAF, ALEXANDER · 1988 to 1999
–
NHLBI NIH HHS HL62284NIDDK NIH HHS DK38165
6 · The paper itself

Abstract

Sudden cardiac death remains one of the most serious medical challenges in Western countries. Increasing evidence in recent years has demonstrated that the n-3 polyunsaturated fatty acids (PUFAs) can prevent fatal ventricular arrhythmias in experimental animals and probably in humans. Dietary supplement of fish oils or intravenous infusion of the n-3 PUFAs prevents ventricular fibrillation caused by ischemia/reperfusion. Similar antiarrhythmic effects of these fatty acids are also observed in cultured mammalian cardiomyocytes. Based on clinical observations and experimental studies in vitro and in vivo, several mechanisms have been postulated for the antiarrhythmic effect of the n-3 PUFAs. The data from our laboratory and others have shown that the n-3 PUFAs are able to affect the activities of cardiac ion channels. The modulation of channel activities, especially voltage-gated Na(+) and L-type Ca(2+) channels, by the n-3 fatty acids may explain, at least partially, the antiarrhythmic action. It is not clear, however, whether one or more than one mechanism involves the beneficial effect of the n-3 PUFAs on the heart. This article summarizes our recent studies on the specific effects of the n-3 PUFAs on cardiac ion channels. In addition, the effect of the n-3 PUFAs on the human hyperpolarization-activated cyclic-nucleotide-modulated channel is presented.

Indexed as

Models, CardiovascularAnimalsArrhythmias, CardiacFatty Acids, Omega-3Heart Conduction SystemHumansIon Channel GatingIon ChannelsFatty Acids, Omega-3Ion Channels

Identifiers

PMID16456724
OpenAlexW1973154574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.