ArticleCancer gene therapy2006
Endostatin therapy reveals a U-shaped curve for antitumor activity.
Article in Cancer gene therapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Polymersome-based nanomedicine for combined cancer therapy.Drug delivery · 2026Review
- Article
- Cell-specific gene therapy driven by an optimized hypoxia-regulated vector reduces choroidal neovascularization.Journal of molecular medicine (Berlin, Germany) · 2018Article
- Serum Endostatin Levels in Oral Squamous Cell Carcinoma.Iranian journal of otorhinolaryngology · 2018Article
- Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.Journal of natural products · 2016Article
- Serum endostatin levels are elevated in colorectal cancer and correlate with invasion and systemic inflammatory markers.British journal of cancer · 2014Article
- Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Fuzzy clustering analysis of osteosarcoma related genes.Pathology oncology research : POR · 2014Article
- Chronic oral exposure to bisphenol A results in a nonmonotonic dose response in mammary carcinogenesis and metastasis in MMTV-erbB2 mice.Environmental health perspectives · 2011Article
- Endostatin enhances radioresponse in breast cancer cells via alteration of substance P levels.Oncology letters · 2011Article
- Two Endogenous Antiangiogenic Inhibitors, Endostatin and Angiostatin, Demonstrate Biphasic Curves in their Antitumor Profiles.Dose-response : a publication of International Hormesis Society · 2011Article
- Potential relevance of bell-shaped and u-shaped dose-responses for the therapeutic targeting of angiogenesis in cancer.Dose-response : a publication of International Hormesis Society · 2010Article
- Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses.Journal of hypertension · 2010Article
- The first draft of the endostatin interaction network.The Journal of biological chemistry · 2009Article
- Molecular interplay between endostatin, integrins, and heparan sulfate.The Journal of biological chemistry · 2009Article
- Combination of antiangiogenesis with chemotherapy for more effective cancer treatment.Molecular cancer therapeutics · 2008Review
- Primary neural stem/progenitor cells expressing endostatin or cytochrome P450 for gene therapy of glioblastoma.Cancer gene therapy · 2008Article
- Successful inhibition of intracranial human glioblastoma multiforme xenograft growth via systemic adenoviral delivery of soluble endostatin and soluble vascular endothelial growth factor receptor-2: laboratory investigation.Journal of neurosurgery · 2008Article
- A review of clinical and molecular prognostic factors in osteosarcoma.Journal of cancer research and clinical oncology · 2008Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Developing continuous systemic delivery of endostatin has been a goal of many laboratories. We have employed a method of gene therapy utilizing different viral constructs. Here, we report that a new serotype of adeno-associated viruses, which incorporates canine endostatin, provides dose-dependent transgene expression in the circulation after intramuscular injection in mice. Elevated levels of endostatin remained stable in the circulation for at least 4 months. In vitro assays determined that the protein expressed was biologically active. Antitumor activities of the above construct demonstrated a U-shape curve, where the maximum activity was observed within a certain critical concentration range. These data suggest that an optimum dose range may be required to achieve therapeutic efficacy in large animal models.
Indexed as
Identifiers
16456550What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.