ArticleAmerican journal of respiratory cell and molecular biology2006
Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginosa.
Article in American journal of respiratory cell and molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 106 citations in OpenAlex.
- Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug-resistant Gram-negatives.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Deciphering an isolated lung phenotype of NKX2-1 frameshift pathogenic variant.Frontiers in pediatrics · 2022Article
- Synergistic Action of Antimicrobial Lung Proteins againstInternational journal of molecular sciences · 2021Article
- Transcription Factor HSF1 Suppresses the Expression of Surfactant Protein D in Cells Infected withPathogens (Basel, Switzerland) · 2021Article
- Contribution of Invariant Natural Killer T Cells to the Clearance ofInternational journal of molecular sciences · 2021Article
- Surfactant Protein-A Function: Knowledge Gained From SP-A Knockout Mice.Frontiers in pediatrics · 2021Review
- Protective effect of extracorporeal membrane pulmonary oxygenation combined with cardiopulmonary resuscitation on post-resuscitation lung injury.World journal of emergency medicine · 2021Article
- Genetic Risk Factors for Idiopathic Pulmonary Fibrosis: Insights into Immunopathogenesis.Journal of inflammation research · 2020Review
- Early Growth Response 1 Deficiency Protects the Host against Pseudomonas aeruginosa Lung Infection.Infection and immunity · 2019Article
- Lung infection caused by Pseudomonas aeruginosa in a CD26/DPP4 deficient F344 rat model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Article
- Increased surfactant protein-D levels in the airways of preterm neonates with sepsis indicated responses to infectious challenges.Acta paediatrica (Oslo, Norway : 1992) · 2019Article
- Alveolar Macrophage Phagocytosis and Bacteria Clearance in Mice.Journal of visualized experiments : JoVE · 2019Article
- Differential Effects of Human SP-A1 and SP-A2 on the BAL Proteome and Signaling Pathways in Response toFrontiers in immunology · 2019Article
- Surfactant protein D attenuates acute lung and kidney injuries in pneumonia-induced sepsis through modulating apoptosis, inflammation and NF-κB signaling.Scientific reports · 2018Article
- Immunolocalization of Surfactant Proteins SP-A, SP-B, SP-C, and SP-D in Infantile Labial Glands and Mucosa.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.American journal of respiratory cell and molecular biology · 2018Article
- Mucosal fluid glycoprotein DMBT1 suppresses twitching motility and virulence of the opportunistic pathogen Pseudomonas aeruginosa.PLoS pathogens · 2017Article
- Alterations of the murine gut microbiome in allergic airway disease are independent of surfactant protein D.Heliyon · 2017Article
- Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli.Innate immunity · 2016Article
- Innate Immune Molecule Surfactant Protein D Attenuates Sepsis-induced Acute Pancreatic Injury through Modulating Apoptosis and NF-κB-mediated Inflammation.Scientific reports · 2015Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Surfactant protein (SP)-A and SP-D, members of the collectin family, are involved in innate host defenses against various bacterial and viral pathogens. In this study, we asked whether SP-A and SP-D enhance clearance of a nonmucoid strain of Pseudomonas aeruginosa from the lungs. We infected mice deficient in SP-A (SP-A-/-), SP-D (SP-D-/-) and both pulmonary collectins (SP-AD-/-) by intratracheal administration of P. aeruginosa. Six hours after infection, bacterial counts were significantly higher in SP-A-/-, SP-D-/-, and SP-AD-/- compared with wild-type (WT) mice. Forty-eight hours after infection, bacterial counts were significantly higher in SP-A-/- mice compared with WT mice and in SP-AD-/- mice compared with WT, SP-A-/-, and SP-D-/- mice. Phagocytosis of the bacteria by alveolar macrophages was decreased in SP-A-/- and SP-D-/- mice. Levels of macrophage inflammatory peptide-2 and IL-6 were more elevated in the lungs of SP-D and SP-AD-/- mice compared with WT mice. There was more infiltration by neutrophils in the lungs of SP-D-/- compared with WT and SP-A-/- mice 48 h after infection. This study shows that SP-A and SP-D enhance pulmonary clearance of P. aeruginosa by stimulating phagocytosis by alveolar macrophages and by modulating the inflammatory response in the lungs. These findings also show that the functions of SP-A and SP-D are not completely redundant in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.