ArticleAmerican journal of respiratory and critical care medicine2006
Associations of tumor necrosis factor G-308A with childhood asthma and wheezing.
Article in American journal of respiratory and critical care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- The -308 G/A polymorphism in TNF-α gene is associated with asthma risk: an update by meta-analysis.Journal of clinical immunology · 2011Pooled it
- An association between asthma and TNF-308G/A polymorphism: meta-analysis.Journal of human genetics · 2006Pooled it
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- The role of gene-ambient air pollution interactions in paediatric asthma.European respiratory review : an official journal of the European Respiratory Society · 2022Review
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- LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model.Journal of bioenergetics and biomembranes · 2020Article
- Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma.Frontiers in pediatrics · 2019Review
- Gene-environment interaction from international cohorts: impact on development and evolution of occupational and environmental lung and airway disease.Seminars in respiratory and critical care medicine · 2015Review
- Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study.Journal of thoracic disease · 2015Review
- Interaction of intercellular adhesion molecule 1 (ICAM1) polymorphisms and environmental tobacco smoke on childhood asthma.International journal of environmental research and public health · 2014Article
- Outdoor air pollution and asthma.Lancet (London, England) · 2014Review
- Allergic diseases and air pollution.Asia Pacific allergy · 2013Article
- TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression.Journal of translational medicine · 2013Article
- Article
- Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries.International journal of environmental research and public health · 2012Article
- Joint analysis for integrating two related studies of different data types and different study designs using hierarchical modeling approaches.Human heredity · 2012Article
- Perinatal gene-gene and gene-environment interactions on IgE production and asthma development.Clinical & developmental immunology · 2012Review
- Unifying candidate gene and GWAS Approaches in Asthma.PloS one · 2010Article
- Toxicogenetics: population-based testing of drug and chemical safety in mouse models.Pharmacogenomics · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleTumor necrosis factor (TNF) mediates a spectrum of airway inflammatory responses, including those to air pollutants, and is an asthma candidate gene. One TNF promoter variant (G-308A) affects expression of TNF and has been associated with inflammatory diseases; however, studies of asthma have been inconsistent. Because ozone produces oxidative stress, increased airway TNF, and inflammation, the associations of the -308 TNF polymorphism with asthma may vary by ozone exposure and variants of oxidant defense genes glutathione-S-transferase (GST) M1 and GSTP1.
objectivesTo investigate the association of TNF G-308A with asthma and wheezing and to determine whether these associations vary with ozone exposure and GSTM1 and GSTP1 genotype.
methodsWe studied associations of TNF-308 genotype with lifetime and current wheezing and asthma among 3,699 children in the Children's Health Study. We examined differences in associations with community ozone and by GSTM1 null and GSTP1 105 Ile/Val (A105G) genotype.
resultsChildren with TNF-308 GG had decreased risk of asthma (odds ratio, 0.8; 95% confidence interval, 0.7-0.9) and lifetime wheezing (odds ratio, 0.8; 95% confidence interval, 0.7-0.9). The protective effects of GG genotype on wheezing outcomes were of greater magnitude in lower compared with higher ozone communities. These findings were replicated in the two cohorts of fourth-grade children recruited in 1993 and 1996. The reduction of the protective effect from the -308 GG genotype with higher ozone exposure was most marked in the GSTM1 null and GSTP1 Ile/Ile groups.
conclusionsThe TNF-308 GG genotype may have a protective role in asthma pathogenesis, depending on airway oxidative stress levels.
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Registered trials
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