ArticleJournal of clinical microbiology2006
Sequencing of hsp65 distinguishes among subsets of the Mycobacterium avium complex.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
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- An unusual genetic switch controlsbioRxiv : the preprint server for biology · 2025Article
- Genotyping and drug susceptibility patterns of Mycobacterium avium subsp. hominissuis isolates from different hosts.Scientific reports · 2025Article
- Detection of a Mixed-Strain Infection with Drug- and Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Comparative genomics of Mycobacterium avium subsp. hominissuis strains within a group of captive lowland tapirs.PloS one · 2025Article
- Evidence ofFrontiers in veterinary science · 2025Article
- Culture-independent detection ofFrontiers in veterinary science · 2025Article
- MALDI-TOF mass spectrometry from nucleic acid: development and evaluation of a novel platform for identification of mycobacteria and detection of genetic markers of resistance.Microbiology spectrum · 2024Article
- Non-tuberculous mycobacteria: occurrence in skin test cattle reactors from official tuberculosis-free herds.Frontiers in veterinary science · 2024Article
- Identification of Significant Pathogenic Nontuberculous Mycobacteria Species from Presumptive TB Patients Using PartialInfection and drug resistance · 2023Article
- Mycobacteriosis in slaughter pigs from South Africa from 1991 to 2002:Frontiers in microbiology · 2023Article
- MALDI-TOF Mass Spectrometry as a Rapid Screening Alternative for Non-tuberculous Mycobacterial Species Identification in the Veterinary Laboratory.Frontiers in veterinary science · 2022Article
- Genetic Involvement ofInternational journal of molecular sciences · 2021Review
- Mycobacterial infections in wild boars (Sus scrofa) from Southern Switzerland: Diagnostic improvements, epidemiological situation and zoonotic potential.Transboundary and emerging diseases · 2021Article
- Genomic features ofGigaByte (Hong Kong, China) · 2021Article
- Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected WithFrontiers in microbiology · 2021Article
- Article
- Differential Genotyping ofMicroorganisms · 2020Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Mycobacterium avium complex consists of epidemiologically distinct subsets. The classification of these subsets is complicated by a number of factors, including the ambiguous results obtained with phenotypic and genetic assays and the recent appreciation that human and avian strains appear to be distinct. In previous work, sequencing based on a 441-bp portion of the hsp65 gene has proven to efficiently classify isolates within the Mycobacterium genus but provides low resolution for distinguishing among members of the M. avium complex. Therefore, in this study, we have targeted the more variable 3' region of the hsp65 gene to determine whether it can effectively discriminate M. avium complex isolates at the levels of species and subspecies. Primers designed for this target consistently generated amplicons for all organisms classified as M. avium complex. Sequences obtained indicate that M. intracellulare is genetically divergent from M. avium organisms, and distinct sequevars were obtained for M. avium subsets, including M. avium subsp. avium (bird type), M. avium subsp. hominissuis, and M. avium subsp. paratuberculosis. In addition, sequence differences served to distinguish bovine from ovine strains of M. avium subsp. paratuberculosis. A unique profile for M. avium subsp. silvaticum was not obtained. These results indicate that sequencing the 3' region of the hsp65 gene can simply and unambiguously distinguish species and subspecies of the M. avium complex.
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