ArticleThe Journal of physiology2006
Limited oxygen diffusion accelerates fatigue development in mouse skeletal muscle.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 89 citations in OpenAlex.
- Trial
- The effect of pH on fatigue during submaximal isometric contractions of the human calf muscle.European journal of applied physiology · 2015Trial
- Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans.The Journal of physiology · 2008Trial
- Microbial-derived Exerkines preserve muscle size and function during disuse in aged mice in a sex-dependent manner.Physiological reports · 2026Article
- Lactic acidosis: implications for human exercise performance.European journal of applied physiology · 2025Review
- Time-of-day effects on muscle mitochondria following short-term ablation of satellite cells.Frontiers in physiology · 2025Article
- Glucose and glycogen affects CaPhysiological reports · 2024Article
- Advanced Methodology for Rapid Isolation of Single Myofibers from Flexor Digitorum Brevis Muscle.Tissue engineering. Part C, Methods · 2023Article
- Neuromuscular fatigability at high altitude: Lowlanders with acute and chronic exposure, and native highlanders.Acta physiologica (Oxford, England) · 2022Review
- Is curvature of the force-velocity relationship affected by oxygen availability? Evidence from studies in ex vivo and in situ rat muscles.Pflugers Archiv : European journal of physiology · 2020Article
- A Single Dose of The Mango Leaf Extract ZynamiteNutrients · 2019Article
- Progressive decrease in leg-power performance during a fatiguing badminton field test.Journal of physical therapy science · 2019Article
- Molecular Basis for Exercise-Induced Fatigue: The Importance of Strictly Controlled Cellular CaCold Spring Harbor perspectives in medicine · 2018Review
- Mechanical isolation, and measurement of force and myoplasmic free [CaNature protocols · 2017Article
- Docetaxel does not impair skeletal muscle force production in a murine model of cancer chemotherapy.Physiological reports · 2017Article
- Forced Running Endurance Is Influenced by Gene(s) on Mouse Chromosome 10.Frontiers in physiology · 2017Article
- Mechanistic Insights into the Efficacy of Sodium Bicarbonate Supplementation to Improve Athletic Performance.Sports medicine - open · 2016Review
- Slow recovery of the impaired fatigue resistance in postunloading mouse soleus muscle corresponding to decreased mitochondrial function and a compensatory increase in type I slow fibers.American journal of physiology. Cell physiology · 2016Article
- Extracellular Ca2+-induced force restoration in K+-depressed skeletal muscle of the mouse involves an elevation of [K+]i: implications for fatigue.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Assessment of muscle mass and strength in mice.BoneKEy reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isolated whole skeletal muscles fatigue more rapidly than isolated single muscle fibres. We have now employed this difference to study mechanisms of skeletal muscle fatigue. Isolated whole soleus and extensor digitorum longus (EDL) muscles were fatigued by repeated tetanic stimulation while measuring force production. Neither application of 10 mm lactic acid nor increasing the [K(+)] of the bath solution from 5 to 10 mm had any significant effect on the rate of force decline during fatigue induced by repeated brief tetani. Soleus muscles fatigued slightly faster during continuous tetanic stimulation in 10 mm[K(+)]. Inhibition of mitochondrial respiration with cyanide resulted in a faster fatigue development in both soleus and EDL muscles. Single soleus muscle fibres were fatigued by repeated tetani while measuring force and myoplasmic free [Ca(2+)] ([Ca(2+)](i)). Under control conditions, the single fibres were substantially more fatigue resistant than the whole soleus muscles; tetanic force at the end of a series of 100 tetani was reduced by about 10% and 50%, respectively. However, in the presence of cyanide, fatigue developed at a similar rate in whole muscles and single fibres, and tetanic force at the end of fatiguing stimulation was reduced by approximately 80%. The force decrease in the presence of cyanide was associated with a approximately 50% decrease in tetanic [Ca(2+)](i), compared with an increase of approximately 20% without cyanide. In conclusion, lactic acid or [K(+)] has little impact on fatigue induced by repeated tetani, whereas hypoxia speeds up fatigue development and this is mainly due to an impaired Ca(2+) release from the sarcoplasmic reticulum.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.