Evidence map›Paper›PMID 16455017›Full record

ReviewCurrent atherosclerosis reports2006

Endothelial cell heterogeneity and atherosclerosis.

William C Aird

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

William C AirdDivision of Molecular and Vascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. waird@bidmc.harvard.edu
Beth Israel Deaconess Medical Center · US

Funding

VASCULAR TOPOGRAPHY OF CD39/NTPDASESP01HL076540 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI OETTGEN, PETER I · 2004 to 2014
$20.3M
NHLBI NIH HHS HL076540
6 · The paper itself

Abstract

Vascular diseases are the most common causes of morbidity and mortality in the Western world. These conditions, whether they involve small and/or large vessels, invariably manifest as localized lesions within the vascular tree. For example, atherosclerosis preferentially affects arteries at branch points, the outer wall of bifurcations, and the inner walls of curvatures. An important question is how systemic alterations in blood-borne factors (eg, those associated with cardiac risk factors) result in focal vasculopathy. A clue to the answer lies in the complex spatial and temporal dynamics of the endothelium. The goal of this review is to highlight concepts of endothelial cell heterogeneity and to apply these principles to an understanding of the pathogenesis, diagnosis, and treatment of atherosclerosis.

Indexed as

AtherosclerosisClinical Trials as TopicEndothelial CellsEndothelium, VascularHumans

Identifiers

PMID16455017
OpenAlexW1977986167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.