ReviewDrug safety2006
Current understanding of contrast media reactions and implications for clinical management.
Review in Drug safety, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 75 citations in OpenAlex.
- Recurrent Intravenous Contrast-Induced Submandibular Sialadenitis: A Case Report and Literature Review.The American journal of case reports · 2026Review
- Characterization and diagnostic evaluation of hypersensitivity to iodinated contrast media: A retrospective analysis.The World Allergy Organization journal · 2026Article
- Acute Adverse Reactions to Nonionic Low-Osmolar Iodinated Contrast Media in Children: A Retrospective Study of 23,429 Injections Over 6 Years.Korean journal of radiology · 2025Article
- Angioedema From Triple Therapy: A Case Report.Cureus · 2023Article
- The value of CA125 in predicting acute complicated colonic diverticulitis.International journal of colorectal disease · 2023Observational
- Pharmacist-led iodinated contrast media infusion risk assessment service.Frontiers in pharmacology · 2023Article
- Bridging the gap between bench and clinic: the importance of understanding the mechanism of iodinated contrast media hypersensitivity.The British journal of radiology · 2023Review
- Machine Learning Model Drift: Predicting Diagnostic Imaging Follow-Up as a Case Example.Journal of the American College of Radiology : JACR · 2022Article
- Emergent Premedication for Contrast Allergy Prior to Endovascular Treatment of Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2020Article
- Article
- Practical administration of intravenous contrast media in children: screening, prophylaxis, administration and treatment of adverse reactions.Pediatric radiology · 2019Review
- Clinical decision support increases diagnostic yield of computed tomography for suspected pulmonary embolism.The American journal of emergency medicine · 2018Article
- Clinical observation of adverse drug reactions to non-ionic iodinated contrast media in population with underlying diseases and risk factors.The British journal of radiology · 2017Article
- Article
- Clinical observation of the adverse drug reactions caused by non-ionic iodinated contrast media: results from 109,255 cases who underwent enhanced CT examination in Chongqing, China.The British journal of radiology · 2015Observational
- Adverse reactions to contrast media: an analysis of spontaneous reports in the database of the pharmacovigilance programme of India.Drug safety · 2014Article
- Comparison of the safety of seven iodinated contrast media.Journal of Korean medical science · 2013Article
- A rare allergy to a polyether dental impression material.Clinical oral investigations · 2012Article
- Influence of MRI contrast media on histamine release from mast cells.Polish journal of radiology · 2012Article
- Previous iodinated contrast anaphylaxis in blunt abdominal trauma: management options.BMJ case reports · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iodinated contrast media (CM) are an integral part of modern diagnostic medicine. Although these agents are considered to be relatively safe, adverse effects in the form of allergy-like reactions occur in a significant number of exposed patients. These reactions may be divided into immediate and delayed responses. Immediate (within 1 hour of administration) anaphylactic reactions range from urticaria and angioedema to laryngeal oedema, hypotension and even death. Delayed reactions to CM occur from 1 hour to 1 week after administration and usually have mostly cutaneous manifestations. History of prior CM reactions and atopy predispose patients to CM reactions. Despite intense research into the pathogenesis of the immediate anaphylactoid responses, new evidence shows that true IgE type I hypersensitivity mediation occurs only in rare, severe cases. The aetiology appears to be multifactorial in most individuals. There is strong evidence to conclude that type IV hypersensitivity is responsible for the delayed reactions to CM. Although switching to non-ionic agents significantly reduces the incidence of immediate reactions to CM, there is little consensus regarding corticosteroid prophylaxis in high-risk individuals. Skin testing and provocative challenges also provide little security. Therefore, physicians must be better prepared to treat immediate anaphylactoid responses. Preventing delayed CM reactions is best performed with patch and delayed intradermal testing in those with a history of prior reactions, although false-negative results have been reported. Corticosteroids and antihistamines may be required for treatment. Until newer agents are developed that negate these issues, healthcare providers must strive to better understand the risk factors associated with CM reactions, as well as the available prophylactic and treatment options.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.