ReviewDrug safety2006
Advances in understanding drug-induced neuropathies.
Review in Drug safety, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- A case of benign recurrent abducens nerve palsy associated with chronic HBV infection.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Preclinical and Clinical Evidence of Therapeutic Agents for Paclitaxel-Induced Peripheral Neuropathy.International journal of molecular sciences · 2021Review
- Vitamin BDrug safety · 2018Review
- Management of a mixed overdose of calcium channel blockers, β-blockers and statins.BMJ case reports · 2014Article
- Idiopathic small fiber neuropathy: phenotype, etiologies, and the search for fabry disease.Journal of clinical neurology (Seoul, Korea) · 2014Article
- Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Abnormal muscle afferent function in a model of Taxol chemotherapy-induced painful neuropathy.Journal of neurophysiology · 2011Article
- Muscle pain in models of chemotherapy-induced and alcohol-induced peripheral neuropathy.Annals of neurology · 2011Article
- My legs are getting old: sinvastatin-induced polyneuropathy.BMJ case reports · 2011Article
- Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy.Current diabetes reports · 2009Review
- Alpha-lipoic acid and frataxin: a new indication for an old antioxidant?Experimental neurology · 2009Article
- Pharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy.Pharmacogenomics · 2009Article
- Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5).American journal of human genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Many commonly used medications have neurotoxic adverse effects; the most common of these is peripheral neuropathy. Neuropathy can be a dose-limiting adverse effect for many medications used in life-threatening conditions, such as malignancy and HIV-related disease. Epidemiological evidence supports previous case reports of HMG-CoA reductase inhibitors (or 'statins') causing an axonal sensorimotor neuropathy or a purely small-fibre neuropathy in some patients. The neuropathy improves when the medication is withdrawn. Despite the association between HMG-CoA reductase inhibitors and neuropathy, the risk is low compared with the significant vascular protective benefits. Oxaliplatin, a new platinum chemotherapy agent designed to have fewer adverse effects than other such agents, has been shown to cause a transient initial dysaesthesia in addition to an axonal polyneuropathy. Thalidomide, an old therapy currently being utilised for new therapeutic indications (e.g. treatment of haematological malignancies), is associated with a painful, axonal sensorimotor neuropathy that does not improve on withdrawal of the drug. Nucleoside reverse transcriptase inhibitors are important components of highly active antiretroviral therapy, but are associated with a sensory neuropathy that is likely to be due to a direct effect of these drugs on mitochondrial DNA replication. New research demonstrates that lactate levels may help discriminate between neuropathy caused by nucleoside analogues and HIV-induced neuropathy. Understanding the mechanism of drug-induced neuropathy has led to advances in preventing this disabling condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.