ArticleMolecular and cellular biology1991
Transcription of muscle-specific genes is repressed by reactivation of pp60v-src in postmitotic quail myotubes.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Src mediates the mechanical activation of myogenesis by activating TNFα-converting enzyme.Journal of cell science · 2013Article
- Distinct roles for N-Cadherin linked c-Src and fyn kinases in lens development.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions.Cellular and molecular life sciences : CMLS · 2012Review
- Microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells.PloS one · 2009Article
- Article
- Article
- Metalloprotease-disintegrin ADAM 12 binds to the SH3 domain of Src and activates Src tyrosine kinase in C2C12 cells.The Biochemical journal · 2000Article
- Distinct effects of Rac1 on differentiation of primary avian myoblasts.Molecular biology of the cell · 1999Article
- Inhibition of src family kinases by a combinatorial action of 5'-AMP and small heat shock proteins, identified from the adult heart.Molecular and cellular biology · 1999Article
- Article
- An essential role of phosphatidylinositol 3-kinase in myogenic differentiation.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Transformation of Rat-1 fibroblasts with the v-src oncogene induces inositol 1,4,5-trisphosphate 3-kinase expression.The Biochemical journal · 1996Article
- The inhibition of cultured myoblast differentiation by the simian virus 40 large T antigen occurs after myogenin expression and Rb up-regulation and is not exerted by transformation-competent cytoplasmic mutants.Journal of virology · 1995Article
- Transcriptional stimulation of the retina-specific QR1 gene upon growth arrest involves a Maf-related protein.Molecular and cellular biology · 1995Article
- Maintenance of the differentiated state in skeletal muscle: activation of v-Src disrupts sarcomeres in quail myotubes.The Journal of cell biology · 1995Article
- Transformation by myc prevents fusion but not biochemical differentiation of C2C12 myoblasts: mechanisms of phenotypic correction in mixed culture with normal cells.The Journal of cell biology · 1994Article
- Transcriptional downregulation of the retina-specific QR1 gene by pp60v-src and identification of a novel v-src-responsive unit.Molecular and cellular biology · 1993Article
- Retinoic acid induces myogenin synthesis and myogenic differentiation in the rat rhabdomyosarcoma cell line BA-Han-1C.The Journal of cell biology · 1992Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quail myogenic cells infected with temperature sensitive (ts) mutants of Rous sarcoma virus (RSV) exhibit a temperature-dependent transformation and block of differentiation. When the cells are allowed to differentiate at the restrictive temperature (41 degrees C) and then shifted back to the permissive temperature (35 degrees C), a sharp reduction in the accumulation of muscle-specific mRNAs is observed, following reactivation of the transforming protein pp60v-src. A kinetic analysis of this down-regulation reveals that the reduction in the accumulation of muscle-specific transcripts occurs fairly rapidly within 6 to 20 h after the shift back, depending on the mRNA analyzed. Studies on transcription of endogenous muscle-specific genes and a transfected chloramphenicol acetyltransferase reporter gene under the control of muscle-specific promoters, at the different temperatures, suggest that the oncogene exerts its control mainly at the transcriptional level. On the contrary, transcription of the CMD1 gene, the avian homolog of the mouse muscle regulatory MyoD gene, is not significantly affected by the oncogene both in proliferating myoblasts and in myotubes shifted back to 35 degrees C. These findings are consistent with the conclusion that v-src blocks myogenesis by controlling transcription of muscle-specific genes independently of cell proliferation. Furthermore, they suggest the existence of an alternative pathway, not requiring the silencing of CMD1 transcription, through which the oncogene exerts its effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.