ArticleThe EMBO journal1986
The cdc22 gene of Schizosaccharomyces pombe encodes a cell cycle-regulated transcript.
Article in The EMBO journal, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Redundant mechanisms prevent mitotic entry following replication arrest in the absence of Cdc25 hyper-phosphorylation in fission yeast.PloS one · 2011Article
- The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.PLoS genetics · 2009Article
- MCB-mediated regulation of cell cycle-specific cdc22+ transcription in fission yeast.Molecular genetics and genomics : MGG · 2003Article
- Cdc18 transcription and proteolysis couple S phase to passage through mitosis.The EMBO journal · 1998Article
- Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.Genes & development · 1997Article
- Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.The EMBO journal · 1997Article
- Domains determining the functional distinction of the fission yeast cell cycle "start" molecules Res1 and Res2.Molecular biology of the cell · 1996Article
- Cell cycle, DNA damage and heat shock regulate suc22+ expression in fission yeast.Molecular & general genetics : MGG · 1996Article
- Positive and negative roles for cdc10 in cell cycle gene expression.Nucleic acids research · 1995Article
- Article
- Analysis of a histone H2A variant from fission yeast: evidence for a role in chromosome stability.Molecular & general genetics : MGG · 1994Article
- Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.The EMBO journal · 1994Article
- res2+, a new member of the cdc10+/SWI4 family, controls the 'start' of mitotic and meiotic cycles in fission yeast.The EMBO journal · 1994Article
- A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.The EMBO journal · 1994Article
- A zinc finger protein controls the onset of premeiotic DNA synthesis of fission yeast in a Mei2-independent cascade.The EMBO journal · 1994Article
- cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.The EMBO journal · 1994Article
- Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle.Molecular and cellular biology · 1994Article
- The activity of S.pombe DSC-1-like factor is cell cycle regulated and dependent on the activity of p34cdc2.The EMBO journal · 1993Article
- Domains of p85cdc10 required for function of the fission yeast DSC-1 factor.Nucleic acids research · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two independent DNA sequences, of 5.6 and 2.4 kb in size, were isolated from Schizosaccharomyces pombe gene libraries on the basis of their ability to rescue the temperature-conditional lethality conferred by a cdc22 mutation. Integration of these sequences into the S.pombe genome by homologous recombination, followed by genetic mapping, demonstrated that the site of integration of the 5.6 kb fragment is tightly linked to the cdc22 locus, while that of the 2.4 kb fragment is unlinked. This shows that the 5.6 kb fragment carries the authentic cdc22 gene while the 2.4 kb fragment carries and extragenic suppressor sequence. The cdc22 transcript was identified by Northern blot analysis and shown to be 3.3 kb in size. The level of the transcript during the cell cycle was investigated in synchronous cultures prepared by elutriation. The cdc22 transcript is cell cycle regulated, reaching a maximum level during late G1/S phase, at least 12-fold higher than the minimum level observed in mid G2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.