ReviewEMBO reports2006
Mechanisms of genetic robustness in RNA viruses.
Review in EMBO reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed.
- Concepts of RNA virus evolution for the design of better antiviral countermeasures.Nature reviews. Microbiology · 2026Review
- The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective.Journal of molecular biology · 2024Review
- Article
- Mutational robustness and the role of buffer genes in evolvability.The EMBO journal · 2024Review
- Gain-of-function mutant of movement protein allows systemic transport of a defective tobacco mosaic virus.iScience · 2022Article
- Review
- Article
- Gene Overlapping as a Modulator ofMicroorganisms · 2022Article
- Recovery of a Far-Eastern Strain of Tick-Borne Encephalitis Virus with a Full-Length Infectious cDNA Clone.Virologica Sinica · 2021Article
- Top Three Strategies of ss(+)RNA Plant Viruses: Great Opportunists and Ecosystem Tuners with a Small Genome.Viruses · 2021Review
- A BioID-derived proximity interactome for SARS-CoV-2 proteins.bioRxiv : the preprint server for biology · 2021Article
- Why are viral genomes so fragile? The bottleneck hypothesis.PLoS computational biology · 2021Article
- Quantifying the Evolutionary Constraints and Potential of Hepatitis C Virus NS5A Protein.mSystems · 2021Article
- Deciphering the SSR incidences across viral members of Coronaviridae family.Chemico-biological interactions · 2020Article
- Adaptation of turnip mosaic potyvirus to a specific niche reduces its genetic and environmental robustness.Virus evolution · 2020Article
- The Signatures of Natural Selection and Molecular Evolution in Fusarium graminearum Virus 1.Frontiers in microbiology · 2020Article
- The phylogenomics of evolving virus virulence.Nature reviews. Genetics · 2018Review
- Evolutionary Virology at 40.Genetics · 2018Review
- Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection.Viruses · 2018Review
- Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution.Annual review of virology · 2018Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two key features of RNA viruses are their compacted genomes and their high mutation rate. Accordingly, deleterious mutations are common and have an enormous impact on viral fitness. In their multicellular hosts, robustness can be achieved by genomic redundancy, including gene duplication, diploidy, alternative metabolic pathways and biochemical buffering mechanisms. However, here we review evidence suggesting that during RNA virus evolution, alternative robustness mechanisms may have been selected. After briefly describing how genetic robustness can be quantified, we discuss mechanisms of intrinsic robustness arising as consequences of RNA-genome architecture, replication peculiarities and quasi-species population dynamics. These intrinsic robustness mechanisms operate efficiently at the population level, despite the mutational sensitivity shown by individual genomes. Finally, we discuss the possibility that viruses might exploit cellular buffering mechanisms for their own benefit, producing a sort of extrinsic robustness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.