Trial reportEuropean journal of clinical nutrition2006
The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women.
Trial report in European journal of clinical nutrition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Pooled it
- Effect of alcohol on blood pressure.The Cochrane database of systematic reviews · 2020Pooled it
- Do grape polyphenols improve metabolic syndrome components? A systematic review.European journal of clinical nutrition · 2017Pooled it
- Pooled it
- The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis.The Lancet. Public health · 2017Pooled it
- Health Effects of Red Wine Consumption: A Narrative Review of an Issue That Still Deserves Debate.Nutrients · 2023Review
- Effects of Alcohol Reduction Interventions on Blood Pressure.Current hypertension reports · 2022Review
- Nutraceuticals as a potential adjunct therapy toward improving vascular health in CKD.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
- Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism.Nutrients · 2019Review
- Grape Pomace: Antioxidant Activity, Potential Effect Against Hypertension and Metabolites Characterization after Intake.Diseases (Basel, Switzerland) · 2018Article
- Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.Antioxidants & redox signaling · 2013Review
- Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians.Therapeutic advances in chronic disease · 2012Article
- Comparison of enzymically glucuronidated flavonoids with flavonoid aglycones in an in vitro cellular model of oxidative stress protection.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo elucidate whether the chronic consumption of dealcoholised red wine (DRW) (polyphenol-rich component) and/or red wine (RW) improves vascular function in hypercholesterolaemic postmenopausal women. DESIGN, SUBJECTS AND
interventionA randomised parallel-arm study. Forty-five hypercholesterolaemic postmenopausal women were randomised into either water, DRW or RW group for 6 weeks following a 4 week washout. Fasting measures of central haemodynamic parameters, arterial wave reflection and endothelial nitric oxide were taken at 0 and 6 weeks.
settingClinic in the School of Public Health, Curtin University.
resultsThere were no significant between group differences in arterial stiffness as measured by augmentation index (AIx) and augmentation pressure (AP). However, a significant within group decrease in AIx (-9%, P=0.02) and AP (-12%, P=0.02) was observed following DRW consumption. No significant changes were observed in central haemodynamic parameters and endothelial nitric oxide levels following DRW and RW consumption, compared to water.
conclusionsNeither the chronic consumption of DRW nor RW improved markers of arterial stiffness, compared to control. However, the significant within group improvements in these indices following the consumption of DRW cannot be overlooked and warrant further investigation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.