ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Critical role of nitric oxide-cGMP cascade in the formation of cAMP-dependent long-term memory.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 116 citations in OpenAlex.
- Critical roles of nicotinic acetylcholine receptors in olfactory memory formation and retrieval in crickets.Frontiers in physiology · 2024Article
- Associations between blood leukocyte DNA methylation and sustained attention in mid-to-late childhood.Epigenomics · 2023Article
- NO Synthesis in Immune-Challenged Locust Hemocytes and Potential Signaling to the CNS.Insects · 2021Article
- Leg amputation modifies coordinated activation of the middle leg muscles in the cricket Gryllus bimaculatus.Scientific reports · 2021Article
- Descending and Ascending Signals That Maintain Rhythmic Walking Pattern in Crickets.Frontiers in robotics and AI · 2021Article
- Critical role of protein kinase G in the long-term balance between defensive and appetitive behaviors induced by aversive stimuli in Aplysia.Behavioural brain research · 2020Article
- Ants learn fast and do not forget: associative olfactory learning, memory and extinction inRoyal Society open science · 2019Article
- CREB-B acts as a key mediator of NPF/NO pathway involved in phase-related locomotor plasticity in locusts.PLoS genetics · 2019Article
- Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia.Behavioural brain research · 2019Article
- Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery.Nitric oxide : biology and chemistry · 2019Review
- Dunce Phosphodiesterase Acts as a Checkpoint for Drosophila Long-Term Memory in a Pair of Serotonergic Neurons.Neuron · 2018Article
- Pharmacologic inhibition of phospholipase C in the brain attenuates early memory formation in the honeybee (Biology open · 2018Article
- Application of a Prediction Error Theory to Pavlovian Conditioning in an Insect.Frontiers in psychology · 2018Article
- Signaling Pathways for Long-Term Memory Formation in the Cricket.Frontiers in psychology · 2018Review
- Roles of Octopamine and Dopamine Neurons for Mediating Appetitive and Aversive Signals in Pavlovian Conditioning in Crickets.Frontiers in physiology · 2017Review
- Interaction of inhibitory and facilitatory effects of conditioning trials on long-term memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Nitric oxide/cGMP/PKG signaling pathway activated by M1-type muscarinic acetylcholine receptor cascade inhibits Na+-activated K+ currents in Kenyon cells.Journal of neurophysiology · 2016Article
- Nitric Oxide: Exploring the Contextual Link with Alzheimer's Disease.Oxidative medicine and cellular longevity · 2016Review
- Activation of NO-cGMP Signaling Rescues Age-Related Memory Impairment in Crickets.Frontiers in behavioral neuroscience · 2016Article
- Knockout crickets for the study of learning and memory: Dopamine receptor Dop1 mediates aversive but not appetitive reinforcement in crickets.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclic AMP pathway plays an essential role in formation of long-term memory (LTM). In some species, the nitric oxide (NO)-cyclic GMP pathway has been found to act in parallel and complementary to the cAMP pathway for LTM formation. Here we describe a new role of the NO-cGMP pathway, namely, stimulation of the cAMP pathway to induce LTM. We have studied the signaling cascade underlying LTM formation by systematically coinjecting various "LTM-inducing" and "LTM-blocking" drugs in crickets. Multiple-trial olfactory conditioning led to LTM that lasted for several days, while memory induced by single-trial conditioning decayed away within several hours. Injection of inhibitors of the enzyme forming NO, cGMP, or cAMP into the hemolymph prior to multiple-trial conditioning blocked LTM, whereas injection of an NO donor, cGMP analog, or cAMP analog prior to single-trial conditioning induced LTM. Induction of LTM by injection of an NO donor or cGMP analog paired with single-trial conditioning was blocked by inhibitors of the cAMP pathway, but induction of LTM by a cAMP analog was unaffected by inhibitors of the NO-cGMP pathway. Inhibitors of cyclic nucleotide-gated channel (CNG channel) or calmodulin-blocked induction of LTM by cGMP analog paired with single-trial conditioning, but they did not affect induction of LTM by cAMP analog. Our findings suggest that the cAMP pathway is a downstream target of the NO-cGMP pathway for the formation of LTM, and that the CNG channel and calcium-calmodulin intervene between the NO-cGMP pathway and the cAMP pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.