ArticleJournal of bacteriology2006
Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress.Cell chemical biology · 2026Article
- Article
- Toward aInternational journal of molecular sciences · 2023Review
- Cysteine-Dependent Conformational Heterogeneity of Shigella flexneri Autotransporter IcsA and Implications of Its Function.Microbiology spectrum · 2022Article
- VirB, a key transcriptional regulator of virulence plasmid genes inJournal of bacteriology · 2021Article
- ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens.Nature communications · 2019Article
- T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP.Cell reports · 2017Article
- Identification of novel substrates of Shigella T3SA through analysis of its virulence plasmid-encoded secretome.PloS one · 2017Article
- TheBiochemistry and biophysics reports · 2016Article
- Molecular and Cellular Mechanisms of Shigella flexneri Dissemination.Frontiers in cellular and infection microbiology · 2016Review
- Analysis on the interaction domain of VirG and apyrase by pull-down assay.Molecules (Basel, Switzerland) · 2014Article
- Elongation factor P and modifying enzyme PoxA are necessary for virulence of Shigella flexneri.Infection and immunity · 2014Article
- Article
- Analysis of Soluble protein complexes in Shigella flexneri reveals the influence of temperature on the amount of lipopolysaccharide.Molecular & cellular proteomics : MCP · 2013Article
- Outer membrane protein A (OmpA): a new player in shigella flexneri protrusion formation and inter-cellular spreading.PloS one · 2012Article
- Common changes in global gene expression induced by RNA polymerase inhibitors in Shigella flexneri.PloS one · 2012Article
- In vivo versus in vitro protein abundance analysis of Shigella dysenteriae type 1 reveals changes in the expression of proteins involved in virulence, stress and energy metabolism.BMC microbiology · 2011Article
- Article
- VirB alleviates H-NS repression of the icsP promoter in Shigella flexneri from sites more than one kilobase upstream of the transcription start site.Journal of bacteriology · 2009Article
- Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein.Molecular microbiology · 2009Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleoside triphosphate-hydrolyzing activity-independent manner, suggesting that it may act as an interaction partner in the process of IcsA localization.
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