ArticleJournal of bacteriology2006
Inhibition of cell division suppresses heterocyst development in Anabaena sp. strain PCC 7120.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Three-dimensional coordination of cell-division site positioning in a filamentous cyanobacterium.PNAS nexus · 2023Article
- A proteolytic pathway coordinates cell division and heterocyst differentiation in the cyanobacteriumProceedings of the National Academy of Sciences of the United States of America · 2022Article
- HetF Protein Is a New Divisome Component in a Filamentous and Developmental Cyanobacterium.mBio · 2021Article
- Article
- Functions of the Essential GeneFrontiers in microbiology · 2021Article
- Structural Determinants and Their Role in Cyanobacterial Morphogenesis.Life (Basel, Switzerland) · 2020Review
- The role of the cytoskeletal proteins MreB and FtsZ in multicellular cyanobacteria.FEBS open bio · 2020Article
- Functional Dissection of Genes Encoding DNA Polymerases Based on Conditional Mutants in the Heterocyst-Forming CyanobacteriumFrontiers in microbiology · 2020Article
- FtsZ of Filamentous, Heterocyst-Forming Cyanobacteria Has a Conserved N-Terminal Peptide Required for Normal FtsZ Polymerization and Cell Division.Frontiers in microbiology · 2018Article
- Diversity of Growth Patterns Probed in Live Cyanobacterial Cells Using a Fluorescent Analog of a Peptidoglycan Precursor.Frontiers in microbiology · 2018Article
- An amidase is required for proper intercellular communication in the filamentous cyanobacteriumProceedings of the National Academy of Sciences of the United States of America · 2017Article
- CyDiv, a Conserved and Novel Filamentous Cyanobacterial Cell Division Protein Involved in Septum Localization.Frontiers in microbiology · 2016Article
- Article
- The regulation of HanA during heterocyst development in cyanobacterium Anabaena sp. PCC 7120.World journal of microbiology & biotechnology · 2014Article
- Biased inheritance of the protein PatN frees vegetative cells to initiate patterned heterocyst differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Transcriptional regulation of the heterocyst patterning gene patA from Anabaena sp. strain PCC 7120.Journal of bacteriology · 2010Article
- Cyanobacterial heterocysts.Cold Spring Harbor perspectives in biology · 2010Review
- The N-acetylmuramic acid 6-phosphate etherase gene promotes growth and cell differentiation of cyanobacteria under light-limiting conditions.Journal of bacteriology · 2010Article
- Bacterial shape: two-dimensional questions and possibilities.Annual review of microbiology · 2010Review
- Compartmentalized function through cell differentiation in filamentous cyanobacteria.Nature reviews. Microbiology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When the filamentous cyanobacterium Anabaena PCC 7120 is exposed to combined nitrogen starvation, 5 to 10% of the cells along each filament at semiregular intervals differentiate into heterocysts specialized in nitrogen fixation. Heterocysts are terminally differentiated cells in which the major cell division protein FtsZ is undetectable. In this report, we provide molecular evidence indicating that cell division is necessary for heterocyst development. FtsZ, which is translationally fused to the green fluorescent protein (GFP) as a reporter, is found to form a ring structure at the mid-cell position. SulA from Escherichia coli inhibits the GTPase activity of FtsZ in vitro and prevents the formation of FtsZ rings when expressed in Anabaena PCC 7120. The expression of sulA arrests cell division and suppresses heterocyst differentiation completely. The antibiotic aztreonam, which is targeted to the FtsI protein necessary for septum formation, has similar effects on both cell division and heterocyst differentiation, although in this case, the FtsZ ring is still formed. Therefore, heterocyst differentiation is coupled to cell division but independent of the formation of the FtsZ ring. Consistently, once the inhibitory pressure of cell division is removed, cell division should take place first before heterocyst differentiation resumes at a normal frequency. The arrest of cell division does not affect the accumulation of 2-oxoglutarate, which triggers heterocyst differentiation. Consistently, a nonmetabolizable analogue of 2-oxoglutarate does not rescue the failure of heterocyst differentiation when cell division is blocked. These results suggest that the control of heterocyst differentiation by cell division is independent of the 2-oxoglutarate signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.