ArticleProceedings of the National Academy of Sciences of the United States of America2006
Crystal structure of human apolipoprotein A-I: insights into its protective effect against cardiovascular diseases.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 204 citations in OpenAlex.
- Case-Control Study to Investigate the Association Between Serum Apolipoprotein B/A1 Ratio and Atrial Fibrillation by Sex in 920 Patients from China.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Large nanodiscs going viral.Current opinion in structural biology · 2020Review
- Article
- Hydrogen-deuterium exchange mass spectrometry of membrane proteins in lipid nanodiscs.Chemistry and physics of lipids · 2019Review
- Covalently circularized nanodiscs; challenges and applications.Current opinion in structural biology · 2018Review
- A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets.Nature communications · 2018Article
- Manipulating trypsin digestion conditions to accelerate proteolysis and simplify digestion workflows in development of protein mass spectrometric assays for the clinical laboratory.Clinical mass spectrometry (Del Mar, Calif.) · 2017Article
- Charge-transfer interactions induce surface dependent conformational changes in apolipoprotein biocorona.Biointerphases · 2017Article
- VIPP1 Has a Disordered C-Terminal Tail Necessary for Protecting Photosynthetic Membranes against Stress.Plant physiology · 2016Article
- Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling.Biochemical Society transactions · 2016Review
- Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy.Nature communications · 2015Article
- Article
- Structural and functional assessment of perilipin 2 lipid binding domain(s).Biochemistry · 2014Article
- Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis.Journal of medicinal chemistry · 2014Review
- New insights into the determination of HDL structure by apolipoproteins: Thematic review series: high density lipoprotein structure, function, and metabolism.Journal of lipid research · 2013Review
- ABCA1 mediates unfolding of apolipoprotein AI N terminus on the cell surface before lipidation and release of nascent high-density lipoprotein.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia.Journal of lipid research · 2013Article
- Comparative proteomic analysis of peritoneal dialysate from chronic glomerulonephritis patients.BioMed research international · 2013Article
- Optimized negative-staining electron microscopy for lipoprotein studies.Biochimica et biophysica acta · 2013Review
- Identification of sites in apolipoprotein A-I susceptible to chymase and carboxypeptidase A digestion.Bioscience reports · 2012Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2018-07-05Concerns/Issues about Data · Investigation by Company/Institution · Investigation by ORI · · H M Krishna Murthy has NIH finding of misconduct - see https://www.federalregister.gov/documents/2018/04/16/2018-07782/findings-of-research-misconduct;
- Expression of concern · 2010-04-06Concerns/Issues about Data · Investigation by Company/Institution · Investigation by ORI · · H M Krishna Murthy has NIH finding of misconduct
- Commented on by
- Expression of concern
- Retracted
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Despite three decades of extensive studies on human apolipoprotein A-I (apoA-I), the major protein component in high-density lipoproteins, the molecular basis for its antiatherogenic function is elusive, in part because of lack of a structure of the full-length protein. We describe here the crystal structure of lipid-free apoA-I at 2.4 A. The structure shows that apoA-I is comprised of an N-terminal four-helix bundle and two C-terminal helices. The N-terminal domain plays a prominent role in maintaining its lipid-free conformation, indicating that mutants with truncations in this region form inadequate models for explaining functional properties of apoA-I. A model for transformation of the lipid-free conformation to the high-density lipoprotein-bound form follows from an analysis of solvent-accessible hydrophobic patches on the surface of the structure and their proximity to the hydrophobic core of the four-helix bundle. The crystal structure of human apoA-I displays a hitherto-unobserved array of positively and negatively charged areas on the surface. Positioning of the charged surface patches relative to hydrophobic regions near the C terminus of the protein offers insights into its interaction with cell-surface components of the reverse cholesterol transport pathway and antiatherogenic properties of this protein. This structure provides a much-needed structural template for exploration of molecular mechanisms by which human apoA-I ameliorates atherosclerosis and inflammatory diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.