ArticleGenetics2006
De novo appearance and "strain" formation of yeast prion [PSI+] are regulated by the heat-shock transcription factor.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeast.G3 (Bethesda, Md.) · 2021Article
- Nucleation seed size determines amyloid clearance and establishes a barrier to prion appearance in yeast.Nature structural & molecular biology · 2020Article
- Article
- Analysis of [SWIMolecular microbiology · 2017Article
- De novo [PSIScientific reports · 2017Article
- Hsp90-Associated Immunophilin Homolog Cpr7 Is Required for the Mitotic Stability of [URE3] Prion in Saccharomyces cerevisiae.PLoS genetics · 2015Article
- Feedback control of prion formation and propagation by the ribosome-associated chaperone complex.Molecular microbiology · 2015Article
- Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast.Molecular biology of the cell · 2015Article
- Article
- Extracellular environment modulates the formation and propagation of particular amyloid structures.Molecular microbiology · 2014Article
- Physiological and environmental control of yeast prions.FEMS microbiology reviews · 2014Review
- Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae.The Journal of biological chemistry · 2013Article
- Prions in yeast.Genetics · 2012Review
- Environmental regulation of prions in yeast.PLoS pathogens · 2012Article
- Destabilization and recovery of a yeast prion after mild heat shock.Journal of molecular biology · 2011Article
- Prion formation and polyglutamine aggregation are controlled by two classes of genes.PLoS genetics · 2011Article
- Distinct subregions of Swi1 manifest striking differences in prion transmission and SWI/SNF function.Molecular and cellular biology · 2010Article
- Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease.PLoS biology · 2010Article
- Article
- The NatA acetyltransferase couples Sup35 prion complexes to the [PSI+] phenotype.Molecular biology of the cell · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Yeast prions are non-Mendelian genetic elements that are conferred by altered and self-propagating protein conformations. Such a protein conformation-based transmission is similar to that of PrP(Sc), the infectious protein responsible for prion diseases. Despite recent progress in understanding the molecular nature and epigenetic transmission of prions, the underlying mechanisms governing prion conformational switch and determining prion "strains" are not understood. We report here that the evolutionarily conserved heat-shock transcription factor (HSF) strongly influences yeast prion formation and strain determination. An hsf1 mutant lacking the amino-terminal activation domain inhibits the yeast prion [PSI+] formation whereas a mutant lacking the carboxyl-terminal activation domain promotes [PSI+] formation. Moreover, specific [PSI+] strains are preferentially formed in these mutants, demonstrating the importance of genetic makeup in determining de novo appearance of prion strains. Although these hsf1 mutants preferentially support the formation of certain [PSI+] strains, they are capable of receiving and faithfully propagating nonpreferable strains, suggesting that prion initiation and propagation are distinct processes requiring different cellular components. Our findings establish the importance of HSF in prion initiation and strain determination and imply a similar regulatory role of mammalian HSFs in the complex etiology of prion disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.