ArticleEnvironmental health perspectives2006
Mortality from ischemic heart disease and diabetes mellitus (type 2) in four U.S. wheat-producing states: a hypothesis-generating study.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- High-Fat Diet Aggravates the Disorder of Glucose Metabolism Caused by Chlorpyrifos Exposure in Experimental Rats.Foods (Basel, Switzerland) · 2023Article
- Increased risk of atherosclerosis associated with pesticide exposure in rural areas in Korea.PloS one · 2020Article
- Exposure to Agrochemicals and Cardiovascular Disease: A Review.International journal of environmental research and public health · 2016Review
- Effects of Environmental Pollutants on Cellular Iron Homeostasis and Ultimate Links to Human Disease.Environmental health insights · 2016Article
- Overview of the National Occupational Mortality Surveillance (NOMS) system: leukemia and acute myocardial infarction risk by industry and occupation in 30 US states 1985-1999, 2003-2004, and 2007.American journal of industrial medicine · 2015Article
- Diabetes: time to look beyond gluttony and laziness.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2011Article
- Assessment of a pesticide exposure intensity algorithm in the agricultural health study.Journal of exposure science & environmental epidemiology · 2010Article
- Pesticide use and myocardial infarction incidence among farm women in the agricultural health study.Journal of occupational and environmental medicine · 2010Article
- Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994.Environmental health : a global access science source · 2010Article
- A multilevel model for comorbid outcomes: obesity and diabetes in the US.International journal of environmental research and public health · 2010Article
- Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.Journal of medicinal chemistry · 2009Article
- Pesticides and myocardial infarction incidence and mortality among male pesticide applicators in the Agricultural Health Study.American journal of epidemiology · 2009Article
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Abstract
In this ecologic study I examined ischemic heart disease (IHD) and diabetes mortality in rural agricultural counties of Minnesota, Montana, North Dakota, and South Dakota, in association with environmental exposure to chlorophenoxy herbicides, using wheat acreage as a surrogate exposure. I collected data on agricultural land use and 1979-1998 mortality from the U.S. Department of Agriculture and the Centers for Disease Control and Prevention websites, respectively. Counties were grouped based on percentage of land area dedicated to wheat farming. Poisson relative risks (RR) and 95% confidence intervals (CIs), comparing high- and medium- with low-wheat counties, were obtained for IHD, the subcategories acute myocardial infarction (AMI) and coronary atherosclerosis (CAS), and diabetes, adjusting for sex, age, mortality cohort, and poverty index. Mortality from IHD was modestly increased (RR = 1.08; 95% CI, 1.04-1.12). Analyses of its two major forms were more revealing. Compared with low-wheat counties, mortality in high-wheat counties from AMI increased (RR = 1.20; 95% CI, 1.14-1.26), and mortality from CAS decreased (RR = 0.89; 95% CI, 0.83-0.96). Mortality from AMI was more pronounced for those < 65 years of age (RR = 1.31; 95% CI 1.22-1.39). Mortality from type 2 diabetes increased (RR = 1.16; 95% CI, 1.08-1.24). These results suggest that the underlying cause of mortality from AMI and type 2 diabetes increased and the underlying cause of mortality from CAS decreased in counties where a large proportion of the land area is dedicated to spring and durum wheat farming. Firm conclusions on causal inference cannot be reached until more definitive studies have been conducted.
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